Trial reportJournal of neurophysiology2021
Sensing and decoding the neural drive to paralyzed muscles during attempted movements of a person with tetraplegia using a sleeve array.
Trial report in Journal of neurophysiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 59 citations in OpenAlex.
- Sensor Inputs and Closed-Loop Neuromodulation in Spinal Cord Injury: From Animal Models to Clinical Translation.Sensors (Basel, Switzerland) · 2026Review
- Innovative Assistive Technologies for Tetraplegia: A Narrative Review of Systematic and Emerging Evidence.Healthcare (Basel, Switzerland) · 2026Review
- Leveraging neural drive to assess hand motor function in individuals with chronic stroke.Journal of neuroengineering and rehabilitation · 2026Article
- High performance sorting of motor unit action potentials with EMUsort.bioRxiv : the preprint server for biology · 2026Article
- Preliminary Investigation of Myoelectric Control of an Assistive Neck Exoskeleton by Individuals With Amyotrophic Lateral Sclerosis.IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society · 2026Article
- Greater muscle electrode distance and fat mass affect motor units identification from high-density surface EMG in the vastus lateralis muscle.Scientific reports · 2025Article
- Predicting Motor Intent from Residual Neck Muscle Activity in Individuals with Neck Weakness from ALS.Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference · 2025Article
- Insights into motor impairment assessment using myographic signals with artificial intelligence: a scoping review.Biomedical engineering letters · 2025Review
- Transcutaneous stimulation of the cervical spinal cord facilitates motoneuron firing and improves hand-motor function after spinal cord injury.Journal of neurophysiology · 2025Article
- MyoGestic: EMG interfacing framework for decoding multiple spared motor dimensions in individuals with neural lesions.Science advances · 2025Article
- A direct spinal cord-computer interface enables the control of the paralysed hand in spinal cord injury.Brain : a journal of neurology · 2024Article
- Design, Fabrication and Evaluation of a Stretchable High-Density Electromyography Array.Sensors (Basel, Switzerland) · 2024Article
- Article
- Decoding hand and wrist movement intention from chronic stroke survivors with hemiparesis using a user-friendly, wearable EMG-based neural interface.Journal of neuroengineering and rehabilitation · 2024Article
- The Forces Generated by Agonist Muscles during Isometric Contractions Arise from Motor Unit Synergies.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Neurocognitive and motor-control challenges for the realization of bionic augmentation.Nature biomedical engineering · 2023Article
- Translation of surface electromyography to clinical and motor rehabilitation applications: The need for new clinical figures.Translational neuroscience · 2023Article
- The science and engineering behind sensitized brain-controlled bionic hands.Physiological reviews · 2022Review
- Editorial: Neuromechanics in Movement and Disease With Physiological and Pathophysiological Implications: From Fundamental Experiments to Bio-Inspired Technologies.Frontiers in physiology · 2022Article
- Properties of the surface electromyogram following traumatic spinal cord injury: a scoping review.Journal of neuroengineering and rehabilitation · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 5 institutions in 3 countries.
Funding
Abstract
Motor neurons convey information about motor intent that can be extracted and interpreted to control assistive devices. However, most methods for measuring the firing activity of single neurons rely on implanted microelectrodes. Although intracortical brain-computer interfaces (BCIs) have been shown to be safe and effective, the requirement for surgery poses a barrier to widespread use that can be mitigated by instead using noninvasive interfaces. The objective of this study was to evaluate the feasibility of deriving motor control signals from a wearable sensor that can detect residual motor unit activity in paralyzed muscles after chronic cervical spinal cord injury (SCI). Despite generating no observable hand movement, volitional recruitment of motor units below the level of injury was observed across attempted movements of individual fingers and overt wrist and elbow movements. Subgroups of motor units were coactive during flexion or extension phases of the task. Single digit movement intentions were classified offline from the electromyogram (EMG) power [root-mean-square (RMS)] or motor unit firing rates with median classification accuracies >75% in both cases. Simulated online control of a virtual hand was performed with a binary classifier to test feasibility of real-time extraction and decoding of motor units. The online decomposition algorithm extracted motor units in 1.2 ms, and the firing rates predicted the correct digit motion 88 ± 24% of the time. This study provides the first demonstration of a wearable interface for recording and decoding firing rates of motor units below the level of injury in a person with motor complete SCI.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.