Evidence map›Paper›PMID 34788146›Full record

ArticleAmerican journal of physiology. Cell physiology2022

Extracellular cysteines C226 and C232 mediate hydrogen sulfide-dependent inhibition of Orai3-mediated store-operated calcium entry.

Adriana M Fresquez, Carl White

Open access · greenAbstract read
In one paragraph

Article in American journal of physiology. Cell physiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.2field-weighted citation impact, top 53% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Adriana M FresquezDiscipline of Physiology and Biophysics, Chicago Medical School, Rosalind Franklin University of Medicine and Science, North Chicago, Illinois.
Carl WhiteDiscipline of Physiology and Biophysics, Chicago Medical School, Rosalind Franklin University of Medicine and Science, North Chicago, Illinois.ORCID 0000-0002-0535-6968
Rosalind Franklin University of Medicine and Science · US

Funding

The contribution of perivascular macrophages to cerebral microvascular dysfunction in Alzheimer'sR01HL142906 · NHLBI · ROSALIND FRANKLIN UNIV OF MEDICINE & SCI · PI WHITE, CARL · 2019 to 2022
$1.9M
NHLBI NIH HHS R01 HL142906
6 · The paper itself

Abstract

The gaseous signaling molecule hydrogen sulfide (H

Indexed as

CalciumCalcium ChannelsCalcium SignalingCysteineExtracellular SpaceHEK293 CellsHumansHydrogen SulfideIntracellular Calcium-Sensing ProteinsMembrane ProteinsNeoplasm ProteinsStromal Interaction Molecule 1CalciumCalcium ChannelsCysteineHydrogen SulfideIntracellular Calcium-Sensing ProteinsMembrane ProteinsNeoplasm ProteinsOrai3 protein, humanSARAF protein, humanSTIM1 protein, humanStromal Interaction Molecule 1calcium storesCRAC channeldisulfidehydrogen sulfide donorstromal interaction molecule 1 (STIM1)

Identifiers

PMID34788146
PMCPMC8759961
OpenAlexW3213548285

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.