ArticleJournal of neurophysiology2021
Evaluation and resolution of many challenges of neural spike sorting: a new sorter.
Article in Journal of neurophysiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 32 citations in OpenAlex.
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- Cortical dynamics in hand/forelimb S1 and M1 evoked by brief photostimulation of the mouse's hand.eLife · 2025Article
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- Neural circuit mechanisms to transform cerebellar population dynamics for motor control in monkeys.bioRxiv : the preprint server for biology · 2025Article
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- Decoding Continuous Tracking Eye Movements from Cortical Spiking Activity.International journal of neural systems · 2025Article
- Realistic mossy fiber input patterns to unipolar brush cells evoke a continuum of temporal responses comprised of components mediated by different glutamate receptors.bioRxiv : the preprint server for biology · 2024Article
- Multi-day neuron tracking in high-density electrophysiology recordings using earth mover's distance.eLife · 2024Article
- A deep-learning strategy to identify cell types across species from high-density extracellular recordings.bioRxiv : the preprint server for biology · 2024Article
- Multi-day Neuron Tracking in High Density Electrophysiology Recordings using EMD.bioRxiv : the preprint server for biology · 2024Article
- A sensory-motor decoder that transforms neural responses in extrastriate area MT into smooth pursuit eye movements.Journal of neurophysiology · 2023Article
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- A sensory-motor decoder that transforms neural responses in extrastriate area MT into smooth pursuit eye movements.bioRxiv : the preprint server for biology · 2023Article
- Rate versus synchrony codes for cerebellar control of motor behavior.bioRxiv : the preprint server for biology · 2023Article
- Manipulation-specific cortical activity as mice handle food.Current biology : CB · 2022Article
- Suppression of crosstalk in multielectrode arrays with local shielding.Frontiers in nanotechnology · 2022Article
- P-sort: an open-source software for cerebellar neurophysiology.Journal of neurophysiology · 2021Article
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3 authors at 1 institution in 1 country.
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Abstract
We evaluate existing spike sorters and present a new one that resolves many sorting challenges. The new sorter, called "full binary pursuit" or FBP, comprises multiple steps. First, it thresholds and clusters to identify the waveforms of all unique neurons in the recording. Second, it uses greedy binary pursuit to optimally assign all the spike events in the original voltages to separable neurons. Third, it resolves spike events that are described more accurately as the superposition of spikes from two other neurons. Fourth, it resolves situations where the recorded neurons drift in amplitude or across electrode contacts during a long recording session. Comparison with other sorters on ground-truth data sets reveals many of the failure modes of spike sorting. We examine overall spike sorter performance in ground-truth data sets and suggest postsorting analyses that can improve the veracity of neural analyses by minimizing the intrusion of failure modes into analysis and interpretation of neural data. Our analysis reveals the tradeoff between the number of channels a sorter can process, speed of sorting, and some of the failure modes of spike sorting. FBP works best on data from 32 channels or fewer. It trades speed and number of channels for avoidance of specific failure modes that would be challenges for some use cases. We conclude that all spike sorting algorithms studied have advantages and shortcomings, and the appropriate use of a spike sorter requires a detailed assessment of the data being sorted and the experimental goals for analyses.
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