ArticleScience advances2021
Lef1 restricts ectopic crypt formation and tumor cell growth in intestinal adenomas.
Open access · goldAbstract read
In one paragraph
Article in Science advances, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 1 pooled it
5.2field-weighted citation impact, top 3% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 29 citations in OpenAlex.
- The Role of Omega-3 Polyunsaturated Fatty Acids in Modulating Inflammation and Breast Cancer: A Systematic Review of In Vitro, Animal, and Human Studies.Current oncology reports · 2026Pooled it
- Progressive intestinal tumor cell plasticity, Myc activation, and loss of Lgr5Science advances · 2026Article
- A TGF-β1/LEF1/β-catenin/JLP network motif regulates autophagy and tubule injury in renal fibrosis.JCI insight · 2026Article
- LEF1 gene mutation impairs the intestinal barrier and causes diarrhea.Molecular and cellular pediatrics · 2026Article
- A Multipotent PROX1+ Tumor Stem/Progenitor Cell Population Emerges during Intestinal Tumorigenesis and Mediates Radioresistance in Colorectal Cancer.Cancer research · 2025Article
- BNC2 as a novel driver of pancreatic cancer progression through transcriptional regulation of COL3A1 and epithelial-to-mesenchymal transition.Medical oncology (Northwood, London, England) · 2025Article
- Single-Cell Dissection of the Serrated Pathway: Cellular Heterogeneity and Genetic Causality in Colorectal Cancer.International journal of molecular sciences · 2025Article
- EGFR controls transcriptional and metabolic rewiring in KRASEMBO molecular medicine · 2025Article
- Decreased expression of LEF1 caused defective decidualization by inhibiting IL-11 expression in patients with adenomyosis.Molecular medicine (Cambridge, Mass.) · 2025Article
- Single-Cell RNA Sequencing Reveals LEF1 as a Prognostic Biomarker for Poor Outcomes in Oxaliplatin-Resistant Colorectal Cancer.Human mutation · 2025Article
- Prevention and treatment of peri-implant fibrosis by functionally inhibiting skeletal cells expressing the leptin receptor.Nature biomedical engineering · 2024Article
- The Interplay among Wnt/β-catenin Family Members in Colorectal Adenomas and Surrounding Tissues.Biomedicines · 2024Article
- DNA Damage-Induced Apoptosis Suppressor Triggers Progression and Stemness of Glioma by Enhancing Lymphoid Enhancer-Binding Factor 1 Expression.World journal of oncology · 2024Article
- Functional analysis reveals driver cooperativity and novel mechanisms in endometrial carcinogenesis.EMBO molecular medicine · 2023Article
- Comprehensive research into prognostic and immune signatures of transcription factor family in breast cancer.BMC medical genomics · 2023Article
- Intestinal Apc-inactivation induces HSP25 dependency.EMBO molecular medicine · 2022Article
- Resveratrol inhibits development of colorectal adenoma via suppression of LEF1; comprehensive analysis with connectivity map.Cancer science · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
16 authors at 7 institutions in 5 countries.
Sarika HeinoTranslational Cancer Medicine Program (CAN-PRO), iCAN Digital Precision Cancer Medicine Flagship and Wihuri Research Institute, Faculty of Medicine, HiLIFE-Helsinki Institute of Life Science, Biomedicum Helsinki, University of Helsinki, 00014 Helsinki, Finland.ORCID 0000-0003-4658-3232
Shentong FangTranslational Cancer Medicine Program (CAN-PRO), iCAN Digital Precision Cancer Medicine Flagship and Wihuri Research Institute, Faculty of Medicine, HiLIFE-Helsinki Institute of Life Science, Biomedicum Helsinki, University of Helsinki, 00014 Helsinki, Finland.ORCID 0000-0002-3520-7007
Marianne LähdeTranslational Cancer Medicine Program (CAN-PRO), iCAN Digital Precision Cancer Medicine Flagship and Wihuri Research Institute, Faculty of Medicine, HiLIFE-Helsinki Institute of Life Science, Biomedicum Helsinki, University of Helsinki, 00014 Helsinki, Finland.
Jenny HögströmTranslational Cancer Medicine Program (CAN-PRO), iCAN Digital Precision Cancer Medicine Flagship and Wihuri Research Institute, Faculty of Medicine, HiLIFE-Helsinki Institute of Life Science, Biomedicum Helsinki, University of Helsinki, 00014 Helsinki, Finland.ORCID 0000-0001-5932-0146
Sina NassiriBioinformatics Core Facility, SIB Swiss Institute of Bioinformatics, Lausanne, Switzerland.
Andrew CampbellCancer Research UK Beatson Institute, Garscube Estate, Glasgow G61 1BD, UK.ORCID 0000-0003-3930-1276
Dustin FlanaganCancer Research UK Beatson Institute, Garscube Estate, Glasgow G61 1BD, UK.ORCID 0000-0002-3915-8281
Alexander RavenCancer Research UK Beatson Institute, Garscube Estate, Glasgow G61 1BD, UK.ORCID 0000-0003-4409-9543
Michael HodderCancer Research UK Beatson Institute, Garscube Estate, Glasgow G61 1BD, UK.
Nadia NasreddinIntestinal Stem Cell Biology Laboratory, Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.ORCID 0000-0002-3025-6213
Hai-Hui XueCenter for Discovery and Innovation, Hackensack University Medical Center, Nutley, NJ 07110, USA.ORCID 0000-0002-9163-7669
Mauro DelorenziBioinformatics Core Facility, SIB Swiss Institute of Bioinformatics, Lausanne, Switzerland.ORCID 0000-0001-7631-3263
Simon LeedhamIntestinal Stem Cell Biology Laboratory, Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.
Tatiana V PetrovaDepartment of Oncology, University of Lausanne and CHUV, Epalinges, Switzerland.ORCID 0000-0002-0563-6521
Owen SansomCancer Research UK Beatson Institute, Garscube Estate, Glasgow G61 1BD, UK.ORCID 0000-0001-9540-3010
Kari AlitaloTranslational Cancer Medicine Program (CAN-PRO), iCAN Digital Precision Cancer Medicine Flagship and Wihuri Research Institute, Faculty of Medicine, HiLIFE-Helsinki Institute of Life Science, Biomedicum Helsinki, University of Helsinki, 00014 Helsinki, Finland.ORCID 0000-0002-7331-0902
Cancer Research UK · GBWihuri Research Institute · FICentre for Human Genetics · GBSIB Swiss Institute of Bioinformatics · CHChina Pharmaceutical University · CNHackensack University Medical Center · USLudwig Cancer Research · CH
Funding
Cancer Research UK 21139Wellcome Trust 206314/Z/17/Z
Abstract
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.