Evidence map›Paper›PMID 34788091›Full record

ArticleScience advances2021

Tracking the ATP-binding response in adenylate kinase in real time.

Fredrik Orädd, Harsha Ravishankar, Jack Goodman, Per Rogne, Lars Backman, Annette Duelli, Martin Nors Pedersen, Matteo Levantino, Michael Wulff, Magnus Wolf-Watz and 1 more

Abstract read
In one paragraph

Article in Science advances, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. BAM 15 Exerts Molluscicidal Effects onMolecules (Basel, Switzerland) · 2026
    Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Review
  15. Article
  16. Article
  17. Article
  18. Protein dynamics: The future is bright and complicated!Structural dynamics (Melville, N.Y.) · 2023
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Fredrik OräddDepartment of Chemistry, Umeå University, Linnaeus Väg 10, 901 87 Umeå, Sweden.ORCID 0000-0002-0706-7414
Harsha RavishankarDepartment of Chemistry, Umeå University, Linnaeus Väg 10, 901 87 Umeå, Sweden.ORCID 0000-0002-8795-6309
Jack GoodmanDepartment of Chemistry, Umeå University, Linnaeus Väg 10, 901 87 Umeå, Sweden.
Per RogneDepartment of Chemistry, Umeå University, Linnaeus Väg 10, 901 87 Umeå, Sweden.
Lars BackmanDepartment of Chemistry, Umeå University, Linnaeus Väg 10, 901 87 Umeå, Sweden.ORCID 0000-0003-3044-1256
Annette DuelliDepartment of Biomedical Sciences, University of Copenhagen, Blegdamsvej 3, 2200 Copenhagen, Denmark.
Martin Nors PedersenESRF-The European Synchrotron, 71 Avenue des Martyrs, CS40220, 38043 Grenoble, Cedex 9, France.
Matteo LevantinoESRF-The European Synchrotron, 71 Avenue des Martyrs, CS40220, 38043 Grenoble, Cedex 9, France.ORCID 0000-0002-1224-4809
Michael WulffESRF-The European Synchrotron, 71 Avenue des Martyrs, CS40220, 38043 Grenoble, Cedex 9, France.ORCID 0000-0003-3784-9019
Magnus Wolf-WatzDepartment of Chemistry, Umeå University, Linnaeus Väg 10, 901 87 Umeå, Sweden.ORCID 0000-0002-9098-7974
Magnus AnderssonDepartment of Chemistry, Umeå University, Linnaeus Väg 10, 901 87 Umeå, Sweden.ORCID 0000-0002-3364-6647

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The biological function of proteins is critically dependent on dynamics inherent to the native structure. Such structural dynamics obey a predefined order and temporal timing to execute the specific reaction. Determination of the cooperativity of key structural rearrangements requires monitoring protein reactions in real time. In this work, we used time-resolved x-ray solution scattering (TR-XSS) to visualize structural changes in the

Identifiers

PMID34788091
PMCPMC8597995

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.