ArticleAnalytical chemistry2021
Manipulation of Ion Types via Gas-Phase Ion/Ion Chemistry for the Structural Characterization of the Glycan Moiety on Gangliosides.
Article in Analytical chemistry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Altering Lipid A Precursor Ion Types in the Gas Phase for In-Depth Structural Elucidation via Tandem Mass Spectrometry.Analytical chemistry · 2025Article
- Special Issue with Research Topics on "Recent Analysis and Applications of Mass Spectra on Biochemistry".International journal of molecular sciences · 2024Article
- Recent Advances in Gas-phase Ion/Ion Chemistry for Lipid Analysis.Trends in analytical chemistry : TRAC · 2023Article
- Article
- Adaptation and Operation of a Quadrupole/Time-of-Flight Tandem Mass Spectrometer for High Mass Ion/Ion Reaction Studies.International journal of mass spectrometry · 2022Article
- Structural characterization and analysis of different epimers of neutral glycosphingolipid LcGg4 by ion mobility spectrometry-mass spectrometry.The Analyst · 2022Article
- Analysis of carbohydrates and glycoconjugates by matrix-assisted laser desorption/ionization mass spectrometry: An update for 2021-2022.Mass spectrometry reviewsReview
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Authors and funding
2 authors.
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Abstract
Gangliosides are the most abundant glycolipid among eukaryotic cell membranes and consist of a glycan head moiety containing one or more sialic acids and a ceramide chain. The analysis of the glycan moieties among different subclass gangliosides, including GM, GD, and GT gangliosides, remains a challenge for shotgun lipidomics. Here, we present a novel shotgun lipidomics approach employing gas-phase ion/ion chemistry. The gas-phase derivatization strategy provides a rapid way to manipulate the ion-types of the precursor ions, and, in conjunction with collision induced dissociation (CID), allows for the elucidation of the structures of the glycan moieties from gangliosides. In addition to the enhancement of structural characterization, gas-phase ion chemistry leads to a form of purification of the precursor ions prior to CID by neutralizing isobaric or isomeric ions with different charge states but with similar or identical
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