Evidence map›Paper›PMID 34787995›Full record

ArticleAnalytical chemistry2021

Multiwindow SRS Imaging Using a Rapid Widely Tunable Fiber Laser.

Hongli Ni, Peng Lin, Yifan Zhu, Meng Zhang, Yuying Tan, Yuewei Zhan, Zian Wang, Ji-Xin Cheng

Abstract read
In one paragraph

Article in Analytical chemistry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Review
  6. Principle of Stimulated Raman Scattering Microscopy: Emerging at High Spatiotemporal Limits.The journal of physical chemistry. C, Nanomaterials and interfaces · 2025
    Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Combinational Vibration Modes in HThe journal of physical chemistry. B · 2023
    Article
  12. Article
  13. Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Hongli NiDepartment of Electrical and Computer Engineering, Boston University, 8 St. Mary's Street, Boston, Massachusetts 02215, United States.ORCID 0000-0003-4323-1493
Peng LinDepartment of Electrical and Computer Engineering, Boston University, 8 St. Mary's Street, Boston, Massachusetts 02215, United States.
Yifan ZhuDepartment of Chemistry, Boston University, 590 Commonwealth Avenue, Boston, Massachusetts 02215, United States.
Meng ZhangDepartment of Biomedical Engineering, Boston University, 44 Cummington Mall, Boston, Massachusetts 02215, United States.
Yuying TanDepartment of Biomedical Engineering, Boston University, 44 Cummington Mall, Boston, Massachusetts 02215, United States.
Yuewei ZhanDepartment of Biomedical Engineering, Boston University, 44 Cummington Mall, Boston, Massachusetts 02215, United States.
Zian WangDepartment of Biomedical Engineering, Boston University, 44 Cummington Mall, Boston, Massachusetts 02215, United States.
Ji-Xin ChengDepartment of Electrical and Computer Engineering, Boston University, 8 St. Mary's Street, Boston, Massachusetts 02215, United States.ORCID 0000-0002-5607-6683

Funding

Vibrational Spectroscopic Imaging to Unveil Hidden Signatures in Living SystemsR35GM136223 · NIGMS · BOSTON UNIVERSITY (CHARLES RIVER CAMPUS) · PI CHENG, JI-XIN · 2020 to 2025
$5.7M
Rapid AST through Metabolic Imaging at Single Cell LevelR01AI141439 · NIAID · BOSTON UNIVERSITY (CHARLES RIVER CAMPUS) · PI Ji-Xin Cheng · 2019 to 2026
$4.7M
Targeting Lipid Unsaturation in Ovarian Cancer Stem CellsR01CA224275 · NCI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Ji-Xin Cheng, Daniela E Matei · 2018 to 2026
$3.6M
NCI NIH HHS R01 CA224275NIAID NIH HHS R01 AI141439NIGMS NIH HHS R35 GM136223
6 · The paper itself

Abstract

Spectroscopic stimulated Raman scattering (SRS) imaging has become a useful tool finding a broad range of applications. Yet, wider adoption is hindered by the bulky and environmentally sensitive solid-state optical parametric oscillator (OPO) in a current SRS microscope. Moreover, chemically informative multiwindow SRS imaging across C-H, C-D, and fingerprint Raman regions is challenging due to the slow wavelength tuning speed of the solid-state OPO. In this work, we present a multiwindow SRS imaging system based on a compact and robust fiber laser with rapid and wide tuning capability. To address the relative intensity noise intrinsic to a fiber laser, we implemented autobalanced detection, which enhances the signal-to-noise ratio of stimulated Raman loss imaging by 23 times. We demonstrate high-quality SRS metabolic imaging of fungi, cancer cells, and

Indexed as

LasersSpectrum Analysis, RamanDiagnostic Tests, RoutineMicroscopySignal-To-Noise Ratio

Identifiers

PMID34787995
PMCPMC9713687

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.