Evidence map›Paper›PMID 34787964›Full record

ArticleCurrent protocols2021

High-Resolution Multi-Isotope Imaging Mass Spectrometry (MIMS) Imaging Applications in Stem Cell Biology.

G McMahon, C P Lechene

Open access · hybridAbstract read
In one paragraph

Article in Current protocols, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Imaging plant metabolism in situ.Journal of experimental botany · 2024
    Review
  5. Observational
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 2 countries.

G McMahonNational Physical Laboratory, Teddington, United Kingdom.
C P LecheneDivision of Genetics, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts.
Brigham and Women's Hospital · USNational Physical Laboratory · GB

Funding

National Resources for Imaging Mass SpectrometryP41EB001974 · NIBIB · BRIGHAM AND WOMEN'S HOSPITAL · PI LECHENE, CLAUDE P · 2004 to 2014
$11.8M
NanoSIMS 50L Ion Micro-AnalyzerS10RR025116 · NCRR · BRIGHAM AND WOMEN'S HOSPITAL · PI LECHENE, CLAUDE P · 2008 to 2008
$2.0M
SPATIAL DYNAMICS OF PROTEIN TURNOVER IN COCHLEAR01DC004179 · NIDCD · BRIGHAM AND WOMEN'S HOSPITAL · PI LECHENE, CLAUDE P · 2000 to 2002
$1.3M
National Resource for Imaging Mass SpectrometryP20EB001974 · NIBIB · BRIGHAM AND WOMEN'S HOSPITAL · PI LECHENE, CLAUDE P · 2003 to 2003
$727k
Cell fate and tissue turnover in the aged studied with multi-isotope imaging massR21AG034641 · NIA · BRIGHAM AND WOMEN'S HOSPITAL · PI LECHENE, CLAUDE P · 2009 to 2010
$489k
NCRR NIH HHS S10 RR025116NIA NIH HHS R21 AG034641NIBIB NIH HHS P20 EB001974NIBIB NIH HHS P41 EB001974NIDCD NIH HHS R01 DC004179
6 · The paper itself

Abstract

Multi-isotope imaging mass spectrometry (MIMS) allows the measurement of turnover of molecules within intracellular compartments with a spatial resolution down to 30 nm. We use molecules enriched in stable isotopes administered to animals by diet or injection, or to cells through the culture medium. The stable isotopes used are, in general,

Indexed as

IsotopesStem CellsAnimalsDiagnostic ImagingIsotope LabelingSpectrometry, Mass, Secondary IonIsotopesBrdUMIMSNanoSIMSOpenMIMSstable isotopesthymidine

Identifiers

PMID34787964
PMCPMC8654063
OpenAlexW3212881564

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.