Evidence map›Paper›PMID 34787828›Full record

ReviewWorld journal of pediatrics : WJP2021

Application of topical gentamicin-a new era in the treatment of genodermatosis.

Shan Wang, Zhou Yang, Ying Liu, Mu-Tong Zhao, Juan Zhao, Huan Zhang, Zong-Yang Liu, Xiao-Ling Wang, Lin Ma, Yong-Hong Yang

Abstract readReview
PubMed Publisher
In one paragraph

Review in World journal of pediatrics : WJP, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.9field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Shan WangDepartment of Dermatology, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, No. 56 South Li Shi Road, Xi Cheng District, Beijing, 100045, China.ORCID http://orcid.org/0000-0003-2177-5318
Zhou YangDepartment of Dermatology, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, No. 56 South Li Shi Road, Xi Cheng District, Beijing, 100045, China.ORCID http://orcid.org/0000-0002-2989-3215
Ying LiuDepartment of Dermatology, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, No. 56 South Li Shi Road, Xi Cheng District, Beijing, 100045, China.ORCID http://orcid.org/0000-0003-4224-5076
Mu-Tong ZhaoDepartment of Dermatology, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, No. 56 South Li Shi Road, Xi Cheng District, Beijing, 100045, China.ORCID http://orcid.org/0000-0002-1885-4579
Juan ZhaoDepartment of Dermatology, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, No. 56 South Li Shi Road, Xi Cheng District, Beijing, 100045, China.
Huan ZhangDepartment of Pharmacy, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, No. 56 South Li Shi Road, Xi Cheng District, Beijing, 100045, China.ORCID http://orcid.org/0000-0002-6516-1249
Zong-Yang LiuDepartment of Pharmacy, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, No. 56 South Li Shi Road, Xi Cheng District, Beijing, 100045, China.
Xiao-Ling WangDepartment of Pharmacy, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, No. 56 South Li Shi Road, Xi Cheng District, Beijing, 100045, China.
Lin Ma *Department of Dermatology, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, No. 56 South Li Shi Road, Xi Cheng District, Beijing, 100045, China. bch_maleen@aliyun.com.ORCID http://orcid.org/0000-0001-7625-9842
Yong-Hong Yang *China National Clinical Research Center for Respiratory Diseases, Department of Respiratory Medicine, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, No. 56 South Li Shi Road, Xi Cheng District, Beijing, 100045, China.
Capital Medical University · CN

Funding

children's medicine research project of beijing children's hospital, capital medical university YZZD202002
6 · The paper itself

Abstract

backgroundThe clinical use of gentamicin always lies in its antimicrobial activity in the past as an aminoglycoside antibiotic. However, in the past decade, there were considerable interests in therapeutic approaches in treating hereditary diseases. Some of the genodermatosis is caused by nonsense mutations that create premature termination codons and lead to the production of truncated or non-functional proteins. Gentamicin could induce readthrough of nonsense mutations and enable the synthesis of full-length proteins. We focus on previous publications on topical application of gentamicin and review its utility in genetic skin diseases. DATA SOURCES: We search the MEDLINE through PubMed, EMBASE databases, and the Clinical Trials Registry Platform from January 1960 to July 2020 using the key search terms "gentamicin, topical gentamicin, genodermatosis, genetic skin diseases".

resultsThe application of gentamicin in genodermatosis yielded promising results, both in vivo and in vitro, including Nagashima-type palmoplantar keratosis, epidermolysis bullosa, Hailey-Hailey disease, hereditary hypotrichosis simplex of the scalp, etc.

conclusionsTopical gentamicin is a potential treatment option for genodermatosis caused by nonsense mutation.

Indexed as

GentamicinsHypotrichosisAnti-Bacterial AgentsCodon, NonsenseHumansAnti-Bacterial AgentsCodon, NonsenseGentamicinsEpidermolysis bullosaGentamicinNagashima-type palmoplantar keratosisNonsense mutationReadthrough

Identifiers

PMID34787828
OpenAlexW3214093860

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.