Evidence map›Paper›PMID 34787795›Full record

ArticleStem cell reviews and reports2022

Application of Human Epineural Conduit Supported with Human Mesenchymal Stem Cells as a Novel Therapy for Enhancement of Nerve Gap Regeneration.

Maria Siemionow, Marcin Michal Strojny, Katarzyna Kozlowska, Sonia Brodowska, Wiktoria Grau-Kazmierczak, Joanna Cwykiel

Open access · hybridAbstract read
In one paragraph

Article in Stem cell reviews and reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.1field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 15 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Maria SiemionowPoznan University of Medical Sciences, Poznan, Poland. siemiom@hotmail.com.ORCID 0000-0001-6372-6122
Marcin Michal StrojnyPoznan University of Medical Sciences, Poznan, Poland.
Katarzyna KozlowskaPoznan University of Medical Sciences, Poznan, Poland.
Sonia BrodowskaDepartment of Orthopaedics, University of Illinois at Chicago, Chicago, IL, USA.
Wiktoria Grau-KazmierczakDepartment of Orthopaedics, University of Illinois at Chicago, Chicago, IL, USA.
Joanna CwykielDepartment of Orthopaedics, University of Illinois at Chicago, Chicago, IL, USA.
Poznan University of Medical Sciences · PLUniversity of Illinois Chicago · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Various therapeutic methods have been suggested to enhance nerve regeneration. In this study, we propose a novel approach for enhancement of nerve gap regeneration by applying human epineural conduit (hEC) supported with human mesenchymal stem cells (hMSC), as an alternative to autograft repair. Restoration of 20 mm sciatic nerve defect with hEC created from human sciatic nerve supported with hMSC was tested in 4 experimental groups (n = 6 each) in the athymic nude rat model (Crl:NIH-Foxn1

Indexed as

Mesenchymal Stem CellsNerve RegenerationAnimalsHumansMuscle, SkeletalRatsSciatic NerveTransplantation, AutologousAutograftHuman Epineural conduitMesenchymal stem cellsNerve regenerationPeripheral nerve repairRegenerative medicine

Identifiers

PMID34787795
PMCPMC8930890
OpenAlexW3214605231

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.