ArticleJournal of cancer survivorship : research and practice2022
The prevalence and risk of symptom and function clusters in colorectal cancer survivors.
Article in Journal of cancer survivorship : research and practice, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.
What it found
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The trial behind it
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Who cites it
20 citing papers in PubMed, 2 syntheses or guidelines pooled it, 24 citations in OpenAlex.
- Symptom clusters in colorectal cancer: a systematic review of assessment tools, statistical methods, and symptom patterns.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025Pooled it
- Pooled it
- A structural equation modeling framework for estimating symptom burden based on symptom clusters in cancer survivors.Scientific reports · 2026Article
- Symptom Clusters and Symptom Burden in Cancer Survivors.Cancer medicine · 2026Article
- The relationship between the latent profiles of cancer-related fatigue characteristics and exercise adherence in colorectal cancer patients.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026Article
- Transcutaneous vagus nerve stimulation in breast cancer: a neuroimmune model to improve quality of life.Frontiers in oncology · 2026Article
- A latent profile analysis of the pain-fatigue-sleep disturbance symptom clusters in postoperative cervical cancer patients: a multicenter cross-sectional study.Frontiers in public health · 2026Article
- Trajectories of Symptom Clusters and Their Predictive Factors in Patients With Colorectal Cancer 3 Months After Surgery: A Longitudinal Study.Cancer medicine · 2025Observational
- Relationship between core symptoms, function, and quality of life in colorectal cancer patients: a network analysis.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2025Article
- Shared decision making in routine oncology appointments with Black patients with lung cancer.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025Observational
- Health-related quality of life profiles of adults with arthritis and/or fibromyalgia: a cross-sectional study.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2025Article
- Beyond mindfulness: the importance of body compassion in colorectal cancer distress.Frontiers in psychology · 2025Article
- Temporal relationship between symptom cluster and quality of life in rectal cancer patients after laparoscopic anus-preserving surgery.Scientific reports · 2024Article
- Prevalence of cancer-related fatigue syndrome and its association with sociodemographic and clinical characteristics in adult patients with colorectal cancer: a cross-sectional study.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2024Article
- Cancer survivor preferences on the timing and content of interventions to mitigate financial toxicity associated with cancer treatment.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2024Article
- Article
- Demographic and Clinical Factors Associated With Health-Related Quality-of-Life Profiles Among Prostate Cancer Survivors.JCO oncology practice · 2024Article
- Stigma, social support, and spirituality: associations with symptoms among Black, Latina, and Chinese American cervical cancer survivors.Journal of cancer survivorship : research and practice · 2024Article
- Relationship between area-level socioeconomic status and health-related quality of life among cancer survivors.JNCI cancer spectrum · 2024Article
- Article
Corrections and comments
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Authors and funding
12 authors at 8 institutions in 1 country.
Funding
Abstract
purposeOur purpose was to describe the prevalence and predictors of symptom and function clusters in a diverse cohort of colorectal cancer survivors.
methodsWe used data from a cohort of 909 adult colorectal cancer survivors. Participants were surveyed at a median of 9 months after diagnosis to ascertain the co-occurrence of eight distinct symptom and functional domains. We used factor analysis to identify co-occurring domains and latent profile analysis (LPA) to identify subgroups of survivors with different symptom and function clusters. Multinomial logistic regression models were used to identify risk/protective factors.
resultsFactor analysis demonstrated a single underlying factor structure that included all eight health domains with depression and anxiety highly correlated (r = 0.87). The LPA identified three symptom and function clusters, with 30% of survivors in the low health-related quality of life (HRQOL) profile having the highest symptom burden and lowest functioning. In multivariable models, survivors more likely to be in the low HRQOL profile included being non-White, female, those with a history of cardiac or mental health conditions, and chemotherapy recipients. Survivors less likely to be in the low HRQOL profile included those with older age, greater financial well-being, and more spirituality.
conclusionNearly one-third of colorectal cancer survivors experienced a cluster of physical and psychosocial symptoms that co-occur with clinically relevant deficits in function. IMPLICATIONS FOR CANCER SURVIVORS: Improving the identification of risk factors for having the highest symptom and lowest function profile can inform the development of clinical interventions to mitigate their adverse impact on cancer survivors' HRQOL.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.