Evidence map›Paper›PMID 34787761›Full record

ReviewBreast cancer research and treatment2022

Classes of therapeutics to amplify the immune response.

Yang Hu, Mark E Burkard

Open access · greenAbstract readReview
In one paragraph

Review in Breast cancer research and treatment, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
0.1field-weighted citation impact, top 51% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it, 1 citations in OpenAlex.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Yang HuDepartment of Medicine, Hematology/Oncology and Palliative Care, University of Wisconsin-Madison, Madison, WI, 53705, USA.
Mark E BurkardDepartment of Medicine, Hematology/Oncology and Palliative Care, University of Wisconsin-Madison, Madison, WI, 53705, USA. mburkard@wisc.edu.ORCID http://orcid.org/0000-0002-4215-7722
University of Wisconsin–Madison · US

Funding

UW COMPREHENSIVE CANCER CENTER SUPPORTP30CA014520 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI Christian Capitini · 1985 to 2026
$142.6M
Viral VectorP30CA086862 · NCI · UNIVERSITY OF IOWA · PI Christopher K Laubenthal · 2000 to 2026
$70.0M
INTEGRATED TRAINING FOR PHYSICIAN-SCIENTISTST32GM008692 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI BURKARD, MARK E · 1998 to 2020
$10.3M
Integrated Training For Physician-ScientistsT32GM140935 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI Anna Huttenlocher, Jeniel E Nett · 2021 to 2026
$6.5M
Impact of chromosomal instability on sensitivity to microtubule-targeting drugs in breast cancerR01CA234904 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI BURKARD, MARK E, WEAVER, BETH A · 2019 to 2023
$2.7M
Mechanisms of paclitaxel sensitivity and resistanceR01CA284747 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI Mark E Burkard, Beth A Weaver · 2024 to 2026
$1.6M
Mitosis, Aneuploidy and CancerR01CA140458 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI WEAVER, BETH A · 2011 to 2015
$1.5M
NCI NIH HHS P30 CA014520NCI NIH HHS P30 CA086862NCI NIH HHS R01 CA140458NCI NIH HHS R01 CA234904NCI NIH HHS R01 CA284747NIGMS NIH HHS T32 GM008692NIGMS NIH HHS T32 GM140935
6 · The paper itself

Abstract

purposeConventional chemotherapies are a mainstay for metastatic breast cancers, though durable response is rare. Immunotherapies promise long-term responses thorough immune activation but have been underwhelming in breast cancer relative to other cancer types. Here, we review the mechanisms of existing strategies including chemotherapies and how they may cause breast cancers to become immunogenic to identify potential biomarkers for combinations of conventional and immunotherapies.

conclusionMechanistic considerations should inform biomarker development and patient selection for therapeutic combinations of drugs to combine with immune-checkpoint inhibitors.

Indexed as

Breast NeoplasmsFemaleHumansImmunityImmunotherapycGAS-STINGImmunogenic cell deathTargeted therapiesTaxaneT-cell activation

Identifiers

PMID34787761
PMCPMC11646685
OpenAlexW3213577070

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.