ArticleeLife2021
Unconventional conservation reveals structure-function relationships in the synaptonemal complex.
Article in eLife, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 31 citations in OpenAlex.
- Structure and function of the synaptonemal complex.The Journal of cell biology · 2026Review
- The synaptonemal complex component corolla regulates meiotic crossover formation in Drosophila melanogaster.Chromosoma · 2025Article
- A proximity labeling approach to identify proteins that associate with synaptonemal complex components inbioRxiv : the preprint server for biology · 2025Article
- The Drosophila mauritiana synaptonemal complex protein C(3)G repatterns the recombination landscape of Drosophila melanogaster.PLoS genetics · 2025Article
- Conservative evolution of genetic and genomic features inbioRxiv : the preprint server for biology · 2025Article
- The synaptonemal complex aligns meiotic chromosomes by wetting.Science advances · 2025Article
- Diversification and recurrent adaptation of the synaptonemal complex in Drosophila.PLoS genetics · 2025Article
- Article
- The synaptonemal complex aligns meiotic chromosomes by wetting.bioRxiv : the preprint server for biology · 2024Article
- A transcriptomics-based RNAi screen for regulators of meiosis and early stages of oocyte development in Drosophila melanogaster.G3 (Bethesda, Md.) · 2024Article
- Skp1 proteins are structural components of the synaptonemal complex inScience advances · 2024Article
- Quercetin as a Promising Antiprotozoan Phytochemical: Current Knowledge and Future Research Avenues.BioMed research international · 2024Review
- Comparative Genomics of Sex, Chromosomes, and Sex Chromosomes in Caenorhabditis elegans and Other Nematodes.Methods in molecular biology (Clifton, N.J.) · 2024Review
- A suppressor screenProceedings of the National Academy of Sciences of the United States of America · 2023Article
- Article
- A suppressor screenbioRxiv : the preprint server for biology · 2023Article
- Building the synaptonemal complex: Molecular interactions between the axis and the central region.PLoS genetics · 2023Review
- A molecular cell biology toolkit for the study of meiosis in the silkworm Bombyx mori.G3 (Bethesda, Md.) · 2023Article
- Article
- Analysis of meiosis ineLife · 2021Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Functional requirements constrain protein evolution, commonly manifesting in a conserved amino acid sequence. Here, we extend this idea to secondary structural features by tracking their conservation in essential meiotic proteins with highly diverged sequences. The synaptonemal complex (SC) is a ~100-nm-wide ladder-like meiotic structure present in all eukaryotic clades, where it aligns parental chromosomes and regulates exchanges between them. Despite the conserved ultrastructure and functions of the SC, SC proteins are highly divergent within
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.