Evidence map›Paper›PMID 34787480›Full record

ArticleEnvironmental health perspectives2021

Ambient Air Pollution in Relation to SARS-CoV-2 Infection, Antibody Response, and COVID-19 Disease: A Cohort Study in Catalonia, Spain (COVICAT Study).

Manolis Kogevinas, Gemma Castaño-Vinyals, Marianna Karachaliou, Ana Espinosa, Rafael de Cid, Judith Garcia-Aymerich, Anna Carreras, Beatriz Cortés, Vanessa Pleguezuelos, Alfons Jiménez and 14 more

Abstract read
In one paragraph

Article in Environmental health perspectives, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
50citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

50 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Ambient Air Pollution and COVID-19 in California.Research report (Health Effects Institute) · 2026
    Article
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  9. Real-life observation of wildfire smoke-impaired COVID-19 vaccine immunity.The Journal of allergy and clinical immunology · 2025
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

24 authors.

Manolis KogevinasBarcelona Institute for Global Health, Barcelona, Spain.ORCID 0000-0002-9605-0461
Gemma Castaño-VinyalsBarcelona Institute for Global Health, Barcelona, Spain.
Marianna KarachaliouBarcelona Institute for Global Health, Barcelona, Spain.ORCID 0000-0002-3014-0747
Ana EspinosaBarcelona Institute for Global Health, Barcelona, Spain.ORCID 0000-0001-7399-3267
Rafael de CidGenomes for Life-GCAT laboratory, Germans Trias i Pujol Research Institute, Badalona, Spain.
Judith Garcia-AymerichBarcelona Institute for Global Health, Barcelona, Spain.
Anna CarrerasGenomes for Life-GCAT laboratory, Germans Trias i Pujol Research Institute, Badalona, Spain.ORCID 0000-0002-8789-067X
Beatriz CortésGenomes for Life-GCAT laboratory, Germans Trias i Pujol Research Institute, Badalona, Spain.
Vanessa PleguezuelosBanc de Sang i Teixits, Barcelona, Spain.
Alfons JiménezBarcelona Institute for Global Health, Barcelona, Spain.
Marta VidalBarcelona Institute for Global Health, Barcelona, Spain.ORCID 0000-0001-6891-7032
Cristina O'Callaghan-GordoBarcelona Institute for Global Health, Barcelona, Spain.
Marta CirachBarcelona Institute for Global Health, Barcelona, Spain.
Rebeca SantanoBarcelona Institute for Global Health, Barcelona, Spain.ORCID 0000-0002-0007-5315
Diana BarriosBarcelona Institute for Global Health, Barcelona, Spain.ORCID 0000-0001-9929-5707
Laura PuyolBarcelona Institute for Global Health, Barcelona, Spain.ORCID 0000-0003-2840-7753
Rocío RubioBarcelona Institute for Global Health, Barcelona, Spain.ORCID 0000-0002-0448-3404
Luis IzquierdoBarcelona Institute for Global Health, Barcelona, Spain.ORCID 0000-0002-3704-9874
Mark NieuwenhuijsenBarcelona Institute for Global Health, Barcelona, Spain.
Payam DadvandBarcelona Institute for Global Health, Barcelona, Spain.ORCID 0000-0002-2325-1027
Ruth AguilarBarcelona Institute for Global Health, Barcelona, Spain.ORCID 0000-0003-3277-3107
Gemma MoncunillBarcelona Institute for Global Health, Barcelona, Spain.ORCID 0000-0001-5105-9836
Carlota DobañoBarcelona Institute for Global Health, Barcelona, Spain.ORCID 0000-0002-6751-4060
Cathryn TonneBarcelona Institute for Global Health, Barcelona, Spain.

Funding

NIAID NIH HHS HHSN272201400008C
6 · The paper itself

Abstract

backgroundEmerging evidence links ambient air pollution with coronavirus 2019 (COVID-19) disease, an association that is methodologically challenging to investigate.

objectivesWe examined the association between long-term exposure to air pollution with SARS-CoV-2 infection measured through antibody response, level of antibody response among those infected, and COVID-19 disease.

methodsWe contacted 9,605 adult participants from a population-based cohort study in Catalonia between June and November 2020; most participants were between 40 and 65 years of age. We drew blood samples from 4,103 participants and measured immunoglobulin M (IgM), IgA, and IgG antibodies against five viral target antigens to establish infection to the virus and levels of antibody response among those infected. We defined COVID-19 disease using self-reported hospital admission, prior positive diagnostic test, or more than three self-reported COVID-19 symptoms after contact with a COVID-19 case. We estimated prepandemic (2018-2019) exposure to fine particulate matter [PM with an aerodynamic diameter of

resultsAmong those tested for SARS-CoV-2 antibodies, 743 (18.1%) were seropositive. Air pollution levels were not statistically significantly associated with SARS-CoV-2 infection: Adjusted RRs per interquartile range were 1.07 (95% CI: 0.97, 1.18) for DISCUSSION: Exposure to air pollution was associated with a higher risk of COVID-19 disease and level of antibody response among infected but not with SARS-CoV-2 infection. https://doi.org/10.1289/EHP9726.

Indexed as

Air PollutantsAir PollutionCOVID-19AdultAgedAntibody FormationCohort StudiesEnvironmental ExposureHumansMiddle AgedNitrogen DioxideParticulate MatterSARS-CoV-2SpainAir PollutantsNitrogen DioxideParticulate Matter

Identifiers

PMID34787480
PMCPMC8597405

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.