Evidence map›Paper›PMID 34787457›Full record

ArticleJournal of virology2022

Jack R Hemsath, A Manuel Liaci, Jeffrey D Rubin, Brian J Parrett, Shao-Chia Lu, Tien V Nguyen, Mallory A Turner, Christopher Y Chen, Karolina Cupelli, Vijay S Reddy and 4 more

Open access · greenAbstract read
In one paragraph

Article in Journal of virology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.9field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 17 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 6 institutions in 3 countries.

Jack R HemsathGraduate Research Employee Program, Mayo Clinicgrid.66875.3a, Rochester, Minnesota, USA.ORCID 0000-0003-1486-9906
A Manuel LiaciInterfaculty Institute of Biochemistry, University of Tübingengrid.10392.39, Tübingen, Germany.
Jeffrey D RubinVirology and Gene Therapy Graduate Program, Mayo Clinicgrid.66875.3a, Rochester, Minnesota, USA.
Brian J ParrettVirology and Gene Therapy Graduate Program, Mayo Clinicgrid.66875.3a, Rochester, Minnesota, USA.
Shao-Chia LuVirology and Gene Therapy Graduate Program, Mayo Clinicgrid.66875.3a, Rochester, Minnesota, USA.
Tien V NguyenDivision of Infectious Diseases, Department of Medicine, Mayo Clinicgrid.66875.3a, Rochester, Minnesota, USA.
Mallory A TurnerVirology and Gene Therapy Graduate Program, Mayo Clinicgrid.66875.3a, Rochester, Minnesota, USA.
Christopher Y ChenDivision of Infectious Diseases, Department of Medicine, Mayo Clinicgrid.66875.3a, Rochester, Minnesota, USA.
Karolina CupelliInterfaculty Institute of Biochemistry, University of Tübingengrid.10392.39, Tübingen, Germany.
Vijay S ReddyDepartment of Integrative Structural and Molecular Biology, The Scripps Research Institute, La Jolla, California, USA.
Thilo StehleInterfaculty Institute of Biochemistry, University of Tübingengrid.10392.39, Tübingen, Germany.ORCID 0000-0002-4571-8548
M Kathryn LiszewskiDivision of Rheumatology, Department of Medicine, Washington University School of Medicine, St. Louis, Missouri, USA.
John P AtkinsonDivision of Rheumatology, Department of Medicine, Washington University School of Medicine, St. Louis, Missouri, USA.
Michael A BarryDivision of Infectious Diseases, Department of Medicine, Mayo Clinicgrid.66875.3a, Rochester, Minnesota, USA.ORCID 0000-0002-8568-5664
Mayo Clinic · USMayo Clinic in Florida · USUniversity of Tübingen · DEWashington University in St. Louis · USScripps Research Institute · USUtrecht University · NL

Funding

Women's Cancer ProgramP30CA015083 · NCI · MAYO CLINIC ROCHESTER · PI Felicity Enders · 1985 to 2026
$151.3M
The Role of Monocytes in non-Hodgkin LymphomaP50CA097274 · NCI · UNIVERSITY OF IOWA · PI WEINER, GEORGE J. · 2002 to 2021
$45.7M
INTRACELLULAR C3 PROTEINS: SOURCE, COMPOSITION, TRAFFICKING AND FUNCTIONR01GM099111 · NIGMS · WASHINGTON UNIVERSITY · PI ATKINSON, JOHN · 2011 to 2019
$2.7M
Defining the Complosome in Human Cells, Tissues and Disease StatesR35GM136352 · NIGMS · WASHINGTON UNIVERSITY · PI ATKINSON, JOHN · 2020 to 2024
$2.0M
PhD Training Program in Virology and Gene TherapyT32AI132165 · NIAID · MAYO CLINIC ROCHESTER · PI ROBERTO B. CATTANEO · 2018 to 2026
$1.3M
Mayo Clinic (The Mayo Clinic) COVID-19 Task ForceMayo Clinic (The Mayo Clinic) Walter & Lucille Rubin Fund in Infectious Diseases Honoring Michael Camilleri, M.D.NCI NIH HHS P30 CA015083NCI NIH HHS P50 CA097274NIAID NIH HHS T32 AI132165NIGMS NIH HHS R01 GM099111NIGMS NIH HHS R35 GM136352University of Iowa/Mayo Clinic Lymphoma Specialized Program of Research Excellence (SPORE) in Lymphoma Developmental Project P50 CA097274
6 · The paper itself

Abstract

Human adenovirus serotype 26 (Ad26) is used as a gene-based vaccine against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and HIV-1. However, its primary receptor portfolio remains controversial, potentially including sialic acid, coxsackie and adenovirus receptor (CAR), integrins, and CD46. We and others have shown that Ad26 can use CD46, but these observations were questioned on the basis of the inability to cocrystallize Ad26 fiber with CD46. Recent work demonstrated that Ad26 binds CD46 with its hexon protein rather than its fiber. We examined the functional consequences of Ad26 for infection

Indexed as

Host-Pathogen InteractionsAdenoviruses, HumanAdenovirus Infections, HumanAnimalsBiomarkersBlood Cell CountCell LineCHO CellsCoxsackie and Adenovirus Receptor-Like Membrane ProteinCricetulusDisease Models, AnimalGene ExpressionHumansMembrane Cofactor ProteinMice, TransgenicModels, BiologicalBiomarkersCD46 protein, humanCoxsackie and Adenovirus Receptor-Like Membrane ProteinMembrane Cofactor ProteinSialic AcidsadenovirusCARCD46gene therapyoncolytic virusesreceptorsvaccines

Identifiers

PMID34787457
PMCPMC8826919
OpenAlexW3212074095

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.