Evidence map›Paper›PMID 34787454›Full record

ArticleJournal of virology2022

The Combined Expression of the Nonstructural Protein NS1 and the N-Terminal Half of NS2 (NS2

Sergio Utrilla-Trigo, Luis Jiménez-Cabello, Eva Calvo-Pinilla, Alejandro Marín-López, Gema Lorenzo, Pedro Sánchez-Cordón, Sandra Moreno, Julio Benavides, Sarah Gilbert, Aitor Nogales and 1 more

Open access · hybridAbstract read
In one paragraph

Article in Journal of virology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
4.0field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 15 citations in OpenAlex.

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  13. Increased Clinical Signs and Mortality in IFNARPathogens (Basel, Switzerland) · 2023
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 3 countries.

Sergio Utrilla-Trigo *Centro de Investigación en Sanidad Animal (CISA), Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria (INIA-CSIC), Valdeolmos, Spain.
Luis Jiménez-Cabello *Centro de Investigación en Sanidad Animal (CISA), Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria (INIA-CSIC), Valdeolmos, Spain.
Eva Calvo-PinillaCentro de Investigación en Sanidad Animal (CISA), Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria (INIA-CSIC), Valdeolmos, Spain.
Alejandro Marín-LópezCentro de Investigación en Sanidad Animal (CISA), Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria (INIA-CSIC), Valdeolmos, Spain.
Gema LorenzoCentro de Investigación en Sanidad Animal (CISA), Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria (INIA-CSIC), Valdeolmos, Spain.
Pedro Sánchez-CordónCentro de Investigación en Sanidad Animal (CISA), Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria (INIA-CSIC), Valdeolmos, Spain.
Sandra MorenoCentro de Investigación en Sanidad Animal (CISA), Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria (INIA-CSIC), Valdeolmos, Spain.
Julio BenavidesInstituto de Ganadería de Montaña (CSIC-Universidad de León), León, Spain.
Sarah GilbertThe Jenner Institute, University of Oxford, Oxford, UK.
Aitor NogalesCentro de Investigación en Sanidad Animal (CISA), Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria (INIA-CSIC), Valdeolmos, Spain.ORCID 0000-0002-2424-7900
Javier OrtegoCentro de Investigación en Sanidad Animal (CISA), Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria (INIA-CSIC), Valdeolmos, Spain.ORCID 0000-0002-4275-7277
Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria · ESInstituto de Ganadería de Montaña · ESUniversity of Oxford · GBYale University · US

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
NCATS NIH HHS UL1 TR001863
6 · The paper itself

Abstract

Bluetongue, caused by bluetongue virus (BTV), is a widespread arthropod-borne disease of ruminants that entails a recurrent threat to the primary sector of developed and developing countries. In this work, we report modified vaccinia virus Ankara (MVA) and ChAdOx1-vectored vaccines designed to simultaneously express the immunogenic NS1 protein and/or NS2-Nt, the N-terminal half of protein NS2 (NS2

Indexed as

AnimalsAntibodies, NeutralizingAntibodies, ViralBluetongueBluetongue virusGenetic VectorsImmunity, CellularImmunizationImmunogenicity, VaccineSerogroupSheepVaccines, DNAVaccinia virusViral Nonstructural ProteinsViral VaccinesAntibodies, NeutralizingAntibodies, ViralVaccines, DNAViral Nonstructural ProteinsViral Vaccinesbluetonguebluetongue virusCD8+ T cell responseDIVAmultiserotypeMVANS1NS2orbivirusesvaccinevaccines

Identifiers

PMID34787454
PMCPMC8826911
OpenAlexW3214136522

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.