Evidence map›Paper›PMID 34787444›Full record

ArticlemSphere2021

Characterization of the Type I Restriction Modification System Broadly Conserved among Group A Streptococci.

Sruti DebRoy, William C Shropshire, Chau Nguyen Tran, Haiping Hao, Marc Gohel, Jessica Galloway-Peña, Blake Hanson, Anthony R Flores, Samuel A Shelburne

Open access · goldAbstract read
In one paragraph

Article in mSphere, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
4.3field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 27 citations in OpenAlex.

  1. Article
  2. Epigenomics identifies three sources of DNA methylation inbioRxiv : the preprint server for biology · 2026
    Article
  3. Article
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  5. The group AInfection and immunity · 2025
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  6. Review
  7. Article
  8. Revisiting typing systems for group BMicrobial genomics · 2024
    Article
  9. An efficientmBio · 2024
    Article
  10. Article
  11. Unraveling the adaptive strategies ofFrontiers in cellular and infection microbiology · 2024
    Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Antimicrobial resistance and mechanisms of epigenetic regulation.Frontiers in cellular and infection microbiology · 2023
    Review
  18. Review
  19. DNA Methyltransferase HsdM Induce Drug Resistance onAntibiotics (Basel, Switzerland) · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Sruti DebRoyDepartment of Infectious Diseases Infection Control and Employee Health, University of Texas MD Anderson Cancer Center, Houston, Texas, USA.ORCID 0000-0001-7328-0443
William C ShropshireDepartment of Infectious Diseases Infection Control and Employee Health, University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
Chau Nguyen TranDepartment of Infectious Diseases Infection Control and Employee Health, University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
Haiping HaoJHMI Transcriptomics and Deep Sequencing Core, Johns Hopkins School of Medicine, Baltimore, Maryland, USA.
Marc GohelDepartment of Infectious Diseases Infection Control and Employee Health, University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
Jessica Galloway-PeñaDepartment of Genomic Medicine, University of Texas MD Anderson Cancer Center, Houston, Texas, USA.ORCID 0000-0003-1081-254X
Blake HansonCenter for Infectious Diseases, Department of Epidemiology, Human Genetics and Environmental Sciences, UTHealth School of Public Health at Houston, University of Texas Health Science Center McGovern Medical School, Houston, Texas, USA.ORCID 0000-0003-2949-7818
Anthony R FloresDivision of Infectious Diseases, Department of Pediatrics, University of Texas Health Science Center McGovern Medical School, Houston, Texas, USA.ORCID 0000-0002-6402-4269
Samuel A ShelburneDepartment of Infectious Diseases Infection Control and Employee Health, University of Texas MD Anderson Cancer Center, Houston, Texas, USA.ORCID 0000-0001-9721-263X
The University of Texas MD Anderson Cancer Center · USJohns Hopkins University · USThe University of Texas Health Science Center at Houston · USUniversity of Texas Health Science Center at Dallas · US

Funding

Novel mechanisms of emergence of hypervirulent group A StreptococcusR21AI132920 · NIAID · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI SHELBURNE, SAMUEL A · 2018 to 2019
$440k
NIAID NIH HHS R21 AI132920
6 · The paper itself

Abstract

Although prokaryotic DNA methylation investigations have long focused on immunity against exogenous DNA, it has been recently recognized that DNA methylation impacts gene expression and phase variation in Streptococcus pneumoniae and Streptococcus suis. A comprehensive analysis of DNA methylation is lacking for beta-hemolytic streptococci, and thus we sought to examine DNA methylation in the major human pathogen group A Streptococcus (GAS). Using a database of 224 GAS genomes encompassing 80

Indexed as

DNA MethylationBacterial ProteinsDNA, BacterialDNA Restriction-Modification EnzymesGene DeletionHumansPhase VariationRegulonStreptococcus pneumoniaeStreptococcus pyogenesVirulenceBacterial ProteinsDNA, BacterialDNA Restriction-Modification EnzymesimmunityStreptococcus pyogenestype I RM system

Identifiers

PMID34787444
PMCPMC8597746
OpenAlexW3212811393

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.