ArticleInfluenza and other respiratory viruses2022
Influenza hospitalizations in Australian children 2010-2019: The impact of medical comorbidities on outcomes, vaccine coverage, and effectiveness.
Article in Influenza and other respiratory viruses, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Risk of SARS-CoV-2 Infection and Hospitalisation in Immunocompromised Children: A Population-Based Cohort Study in Italy and Norway.Acta paediatrica (Oslo, Norway : 1992) · 2026Article
- Pediatric hospitalization profile in Australia: A longitudinal ecological study, 1998 to 2019.Medicine · 2026Article
- Epidemiological characteristics analysis of childhood influenza A virus infections in Hebei, China (2020-2024).Frontiers in pediatrics · 2026Article
- Research trends and key contributors in studies on influenza vaccines for children: A 20-year bibliometric analysis.Human vaccines & immunotherapeutics · 2025Article
- Risk Groups for Vaccine-Preventable Respiratory Infections in Children and Adults: An Overview of the Australian Environment.Vaccines · 2025Review
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- A Narrative Review of Key Risk Factors for Severe Illness Following SARS-CoV-2, Influenza Virus, and Respiratory Syncytial Virus Infection.Infectious diseases and therapy · 2025Review
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- Influenza Epidemiology and Vaccine Effectiveness Following Funded Influenza Vaccine in Queensland, Australia, 2022.Influenza and other respiratory viruses · 2024Article
- Respiratory Viral Testing Rate Patterns in Young Children Attending Tertiary Care Across Western Australia: A Population-Based Birth Cohort Study.Influenza and other respiratory viruses · 2024Article
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- Influenza vaccination in Western Australian children: Exploring the health benefits and cost savings of increased vaccine coverage in children.Vaccine: X · 2023Article
- Influenza hospitalizations in Australian children 2010-2019: The impact of medical comorbidities on outcomes, vaccine coverage, and effectiveness.Influenza and other respiratory viruses · 2022Article
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13 authors.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundChildren with comorbidities are at greater risk of severe influenza outcomes compared with healthy children. In Australia, influenza vaccination was funded for those with comorbidities from 2010 and all children aged <5 years from 2018. Influenza vaccine coverage remains inadequate in children with and without comorbidities.
methodsChildren ≤16 years admitted with acute respiratory illness and tested for influenza at sentinel hospitals were evaluated (2010-2019). Multivariable regression was used to identify predictors of severe outcomes. Vaccine effectiveness was estimated using the modified incidence density test-negative design.
resultsOverall, 6057 influenza-confirmed hospitalized cases and 3974 test-negative controls were included. Influenza A was the predominant type (68.7%). Comorbidities were present in 40.8% of cases. Children with comorbidities were at increased odds of ICU admission, respiratory support, longer hospitalizations, and mortality. Specific comorbidities including neurological and cardiac conditions increasingly predisposed children to severe outcomes. Influenza vaccine coverage in influenza negative children with and without comorbidities was low (33.5% and 17.9%, respectively). Coverage improved following introduction of universal influenza vaccine programs for children <5 years. Similar vaccine effectiveness was demonstrated in children with (55% [95% confidence interval (CI): 45; 63%]) and without comorbidities (57% [(95%CI: 44; 67%]).
conclusionsComorbidities were present in 40.8% of influenza-confirmed admissions and were associated with more severe outcomes. Children with comorbidities were more likely experience severe influenza with ICU admission, mechanical ventilation, and in-hospital morality. Despite demonstrated vaccine effectiveness in those with and without comorbidities, vaccine coverage was suboptimal. Interventions to increase vaccination are expected to reduce severe influenza outcomes.
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