Trial reportSao Paulo medical journal = Revista paulista de medicina
Effects of isometric handgrip training on blood pressure among hypertensive patients seen within public primary healthcare: a randomized controlled trial.
Trial report in Sao Paulo medical journal = Revista paulista de medicina. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 14 papers, 6 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effect of Handgrip's Isometric Training on Blood Pressure and on the Autonomic Modulation of Hypertense Individuals at the Basic Health Units: A Multicentric Study
Effect of Isometric Handgrip Exercises on Blood Pressure of Hypertensive Adults
Who cites it
14 citing papers in PubMed, 6 syntheses or guidelines pooled it, 30 citations in OpenAlex.
- Isometric hand grip training on populations with different baseline resting blood pressure: a systematic review and meta-analysis.BMC public health · 2026Pooled it
- The Optimal Dosage of Isometric Handgrip Exercise for Blood Pressure Reduction: Systematic Review and Meta-Analysis.Journal of clinical hypertension (Greenwich, Conn.) · 2026Pooled it
- The effect of long-term isometric contraction training intervention on blood pressure normalization in prehypertensive individuals: a systematic review and meta-analysis.BMC cardiovascular disorders · 2026Pooled it
- Effects of isometric training based on the entire population on blood pressure regulation: systematic review and meta-analysis of randomized controlled trials.Frontiers in public health · 2026Pooled it
- Isometric handgrip training, but not a single session, reduces blood pressure in individuals with hypertension: a systematic review and meta-analysis.Journal of human hypertension · 2023Pooled it
- Isometric Resistance Training to Manage Hypertension: Systematic Review and Meta-analysis.Current hypertension reports · 2023Pooled it
- Reductions in systolic blood pressure achieved by hypertensives with three isometric training sessions per week are maintained with a single session per week.Journal of clinical hypertension (Greenwich, Conn.) · 2023Trial
- Additional blood-pressure-lowering effect of exercise in adults on stable antihypertensive medication: a systematic review and meta-analysis of randomised controlled trials.Hypertension research : official journal of the Japanese Society of Hypertension · 2026Review
- Efficacy and Cost-Effective Treatment of Isometric Resistance Training for Blood Pressure Control: A Narrative Review in Healthy Individuals and People with Cardiovascular Diseases.Journal of functional morphology and kinesiology · 2026Review
- Optimizing Isometric Handgrip Training for Hypertension: Insights and Gaps in Exercise Configuration.Journal of clinical hypertension (Greenwich, Conn.) · 2026Article
- Efficacy and moderators of isometric resistance training (IRT) on resting blood pressure among patients with pre- to established hypertension: a multilevel meta-review and regression analysis.BMC sports science, medicine & rehabilitation · 2025Article
- Experiences, acceptability and feasibility of an isometric exercise intervention for stage 1 hypertension: embedded qualitative study in a randomised controlled feasibility trial.Pilot and feasibility studies · 2024Article
- Isometric Exercise Training and Arterial Hypertension: An Updated Review.Sports medicine (Auckland, N.Z.) · 2024Review
- Capoeira: hypothesis on health rehabilitation and quality-of-life maintenance.Revista da Associacao Medica Brasileira (1992) · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 6 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMeta-analyses have demonstrated that isometric handgrip training (IHT) decreases blood pressure in hypertensive individuals. Nonetheless, most studies were conducted in laboratory settings and its effects in real-world settings remain unclear.
objectiveTo analyze the effects of IHT on office and ambulatory blood pressure in hypertensive patients attended within primary healthcare. DESIGN AND
settingRandomized controlled trial conducted in primary healthcare units within the Family Health Program, Petrolina, Pernambuco, Brazil.
methods63 hypertensive patients (30-79 years old; 70% female) were randomly allocated into IHT or control groups. IHT was performed three times per week (4 x 2 minutes at 30% of maximal voluntary contraction, one-minute rest between bouts, alternating the hands). Before and after the 12-week training period, office and ambulatory blood pressure and heart rate variability were obtained. The significance level was set at P < 0.05 (two-tailed testing) for all analyses.
resultsIHT significantly decreased office systolic blood pressure (IHT: 129 ± 4 versus 121 ± 3 mmHg, P < 0.05; control: 126 ± 4 versus 126 ± 3 mmHg, P > 0.05), whereas there was no effect on diastolic blood pressure (IHT: 83 ± 3 versus 79 ± 2 mmHg, P > 0.05; control: 81 ± 3 versus 77 ± 3 mmHg, P > 0.05). Heart rate variability and ambulatory blood pressure were not altered by the interventions (P > 0.05 for all).
conclusionIHT reduced office systolic blood pressure in hypertensive patients attended within primary care. However, there were effects regarding diastolic blood pressure, ambulatory blood pressure or heart rate variability. CLINICALTRIALS.GOV IDENTIFIER: NCT03216317.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.