Evidence map›Paper›PMID 34787148›Full record

ArticleLab on a chip2021

Rapid prototyping of cell culture microdevices using parylene-coated 3D prints.

Brian J O'Grady, Michael D Geuy, Hyosung Kim, Kylie M Balotin, Everett R Allchin, David C Florian, Neelansh N Bute, Taylor E Scott, Gregory B Lowen, Colin M Fricker and 5 more

Abstract read
In one paragraph

Article in Lab on a chip, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed.

  1. Article
  2. Parylenes in bioanalytical and cell culture applications.Analytical and bioanalytical chemistry · 2026
    Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Comparison of cytokine responses to group BInfection and immunity · 2025
    Article
  11. Augmented 3D Printing for Multiscale Microphysiological Systems.Small (Weinheim an der Bergstrasse, Germany) · 2025
    Review
  12. Article
  13. Article
  14. SLICK: A Sandwich-LIke Culturing Kit forbioRxiv : the preprint server for biology · 2025
    Article
  15. Article
  16. Modular cone-and-plate device for mechanofluidic assays in Transwell inserts.Frontiers in bioengineering and biotechnology · 2025
    Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Brian J O'GradyDepartment of Chemical and Biomolecular Engineering, Vanderbilt University, Nashville, TN, USA. brian.ogrady@vanderbilt.edu.ORCID 0000-0002-4648-5096
Michael D GeuyVanderbilt Institute for Integrative Biosystems Research and Education, Vanderbilt University, Nashville, TN, USA.ORCID 0000-0002-8531-8880
Hyosung KimDepartment of Chemical and Biomolecular Engineering, Vanderbilt University, Nashville, TN, USA. brian.ogrady@vanderbilt.edu.
Kylie M BalotinDepartment of Biomedical Engineering, Vanderbilt University, Nashville, TN, USA.
Everett R AllchinDepartment of Chemical and Biomolecular Engineering, Vanderbilt University, Nashville, TN, USA. brian.ogrady@vanderbilt.edu.
David C FlorianDepartment of Biomedical Engineering, Vanderbilt University, Nashville, TN, USA.
Neelansh N ButeVanderbilt Brain Institute, Vanderbilt University, Nashville, TN, USA.
Taylor E ScottDepartment of Chemical and Biomolecular Engineering, Vanderbilt University, Nashville, TN, USA. brian.ogrady@vanderbilt.edu.
Gregory B LowenDepartment of Chemical and Biomolecular Engineering, Vanderbilt University, Nashville, TN, USA. brian.ogrady@vanderbilt.edu.
Colin M FrickerVanderbilt Brain Institute, Vanderbilt University, Nashville, TN, USA.
Matthew L FitzgeraldDepartment of Mechanical Engineering, Vanderbilt University, Nashville, TN, USA.
Scott A GuelcherDepartment of Chemical and Biomolecular Engineering, Vanderbilt University, Nashville, TN, USA. brian.ogrady@vanderbilt.edu.ORCID 0000-0002-9871-8058
John P WikswoVanderbilt Institute for Integrative Biosystems Research and Education, Vanderbilt University, Nashville, TN, USA.
Leon M BellanDepartment of Mechanical Engineering, Vanderbilt University, Nashville, TN, USA.ORCID 0000-0001-7181-2194
Ethan S LippmannDepartment of Chemical and Biomolecular Engineering, Vanderbilt University, Nashville, TN, USA. brian.ogrady@vanderbilt.edu.ORCID 0000-0001-5703-5747

Funding

TRAINING PROGRAM IN ENVIRONMENTAL TOXICOLOGYT32ES007028 · NIEHS · VANDERBILT UNIVERSITY · PI F PETER Guengerich, Fiona Edith Harrison · 1985 to 2026
$15.7M
Overall: Eunice Kennedy Shriver Intellectual and Developmental Disabilities Research Center at VanderbiltP50HD103537 · NICHD · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Lea K Davis · 2020 to 2026
$10.3M
Vanderbilt Interdisciplinary Training Program in Alzheimer's DiseaseT32AG058524 · NIA · VANDERBILT UNIVERSITY · PI ANGELA L. JEFFERSON · 2018 to 2026
$3.5M
iPSC-derived Neurovascular OrganoidsR01NS110665 · NINDS · VANDERBILT UNIVERSITY · PI LIPPMANN, ETHAN · 2020 to 2024
$2.5M
Modeling developmental gradients and supportive tissue signaling networks using iPSC-derived forebrain organoids embedded in fluidic hydrogelsRF1MH123971 · NIMH · VANDERBILT UNIVERSITY · PI BELLAN, LEON MARCEL, GAMA, VIVIAN · 2020 to 2020
$2.3M
iPSC-derived neurovascular tissue model of cerebral amyloiad angiopathyR61NS112445 · NINDS · VANDERBILT UNIVERSITY · PI LIPPMANN, ETHAN · 2020 to 2020
$832k
Directing polarized organization in human brain organoids using gradients of soluble signaling factors in a hydrogelR21NS116257 · NINDS · VANDERBILT UNIVERSITY · PI BELLAN, LEON MARCEL · 2020 to 2021
$412k
NIA NIH HHS T32 AG058524NICHD NIH HHS P50 HD103537NIEHS NIH HHS T32 ES007028NIMH NIH HHS RF1 MH123971NINDS NIH HHS R01 NS110665NINDS NIH HHS R21 NS116257NINDS NIH HHS R61 NS112445
6 · The paper itself

Abstract

Fabrication of microfluidic devices by photolithography generally requires specialized training and access to a cleanroom. As an alternative, 3D printing enables cost-effective fabrication of microdevices with complex features that would be suitable for many biomedical applications. However, commonly used resins are cytotoxic and unsuitable for devices involving cells. Furthermore, 3D prints are generally refractory to elastomer polymerization such that they cannot be used as master molds for fabricating devices from polymers (

Indexed as

Lab-On-A-Chip DevicesPolymersCell Culture TechniquesHumansReproducibility of ResultsXylenesparylenePolymersXylenes

Identifiers

PMID34787148
PMCPMC8717820

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.