Evidence map›Paper›PMID 34787131›Full record

ReviewChemical Society reviews2021

Nanomaterial-based bioorthogonal nanozymes for biological applications.

Stefano Fedeli, Jungkyun Im, Sanjana Gopalakrishnan, James L Elia, Aarohi Gupta, Dongkap Kim, Vincent M Rotello

Abstract readReview
In one paragraph

Review in Chemical Society reviews, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed.

  1. Article
  2. Can nanozymes achieve more than enzymes?Nature reviews. Materials · 2026
    Article
  3. Article
  4. Review
  5. Article
  6. N-Heterocyclic Carbenes as Ligands toJournal of medicinal chemistry · 2025
    Article
  7. Article
  8. Article
  9. Article
  10. Exploring New Bioorthogonal Catalysts: Scaffold Diversity in Catalysis for Chemical Biology.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Review
  11. Article
  12. Article
  13. Article
  14. [Advances in the Application of Nanozymes in Joint Disease Therapy].Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 2024
    Review
  15. Article
  16. Modular Fabrication of Bioorthogonal Nanozymes for Biomedical Applications.Advanced materials (Deerfield Beach, Fla.) · 2024
    Review
  17. Article
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Stefano FedeliDepartment of Chemistry, University of Massachusetts Amherst, 710 North Pleasant Street, Amherst, Massachusetts 01003, USA. rotello@chem.umass.edu.ORCID http://orcid.org/0000-0002-1097-6926
Jungkyun ImDepartment of Chemistry, University of Massachusetts Amherst, 710 North Pleasant Street, Amherst, Massachusetts 01003, USA. rotello@chem.umass.edu.ORCID http://orcid.org/0000-0002-7926-5815
Sanjana GopalakrishnanDepartment of Chemistry, University of Massachusetts Amherst, 710 North Pleasant Street, Amherst, Massachusetts 01003, USA. rotello@chem.umass.edu.ORCID http://orcid.org/0000-0003-0590-0545
James L EliaDepartment of Chemistry, University of Massachusetts Amherst, 710 North Pleasant Street, Amherst, Massachusetts 01003, USA. rotello@chem.umass.edu.ORCID http://orcid.org/0000-0003-3962-7452
Aarohi GuptaDepartment of Chemistry, University of Massachusetts Amherst, 710 North Pleasant Street, Amherst, Massachusetts 01003, USA. rotello@chem.umass.edu.ORCID http://orcid.org/0000-0003-1303-1159
Dongkap KimDepartment of Chemistry, University of Massachusetts Amherst, 710 North Pleasant Street, Amherst, Massachusetts 01003, USA. rotello@chem.umass.edu.
Vincent M RotelloDepartment of Chemistry, University of Massachusetts Amherst, 710 North Pleasant Street, Amherst, Massachusetts 01003, USA. rotello@chem.umass.edu.ORCID http://orcid.org/0000-0002-5184-5439

Funding

Targeting of Bio-orthogonal Chemotherapeutic Nanozymes to Tumor-Associated MacrophagesR01EB022641 · NIBIB · UNIVERSITY OF MASSACHUSETTS AMHERST · PI ROTELLO, VINCENT M. · 2017 to 2024
$3.0M
NIBIB NIH HHS R01 EB022641
6 · The paper itself

Abstract

Bioorthogonal transformations are chemical reactions that use pathways which biological processes do not access. Bioorthogonal chemistry provides new approaches for imaging and therapeutic strategies, as well as tools for fundamental biology. Bioorthogonal catalysis enables the development of bioorthogonal "factories" for on-demand and

Indexed as

NanostructuresTransition ElementsCatalysisTissue DistributionTransition Elements

Identifiers

PMID34787131
PMCPMC8862209

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.