Evidence map›Paper›PMID 34787099›Full record

ArticlePhysics in medicine and biology2021

DNA damage modeled with Geant4-DNA: effects of plasmid DNA conformation and experimental conditions.

N D-Kondo, E Moreno-Barbosa, V Štěphán, K Stefanová, Y Perrot, C Villagrasa, S Incerti, B De Celis Alonso, J Schuemann, B Faddegon and 1 more

Open access · greenAbstract read
In one paragraph

Article in Physics in medicine and biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.6field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 16 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 6 institutions in 4 countries.

N D-KondoFaculty of Mathematics and Physics Sciences, Benemérita Universidad Autónoma de Puebla, Puebla, Mexico.
E Moreno-BarbosaFaculty of Mathematics and Physics Sciences, Benemérita Universidad Autónoma de Puebla, Puebla, Mexico.ORCID 0000-0002-1114-2640
V ŠtěphánDepartment of Radiation Dosimetry, Nuclear Physics Institute of the Czech Academy of Sciences, Prague, Czech Republic.
K StefanováDepartment of Radiation Dosimetry, Nuclear Physics Institute of the Czech Academy of Sciences, Prague, Czech Republic.
Y PerrotLaboratoire de Dosimétrie des Rayonnements Ionisants, Institut de Radioprotection et Sûreté Nucléaire, Fontenay aux Roses, BP. 17, F-92262, France.ORCID 0000-0001-9043-5857
C VillagrasaLaboratoire de Dosimétrie des Rayonnements Ionisants, Institut de Radioprotection et Sûreté Nucléaire, Fontenay aux Roses, BP. 17, F-92262, France.
S IncertiUniv. Bordeaux, CNRS/IN2P3, CENBG, UMR 5797, F-33170 Gradignan, France.ORCID 0000-0002-0619-2053
B De Celis AlonsoFaculty of Mathematics and Physics Sciences, Benemérita Universidad Autónoma de Puebla, Puebla, Mexico.ORCID 0000-0003-2124-1084
J SchuemannDepartment of Radiation Oncology, Massachusets General Hospital and Hardvard Medical School, Boston, MA, United States of America.ORCID 0000-0002-7554-8818
B FaddegonDepartment of Radiation Oncology, University of California San Francisco, San Francisco, CA, United States of America.
J Ramos-MéndezDepartment of Radiation Oncology, University of California San Francisco, San Francisco, CA, United States of America.ORCID 0000-0002-8106-5142
Czech Academy of Sciences, Nuclear Physics Institute · CZInstitut de Radioprotection et de Sûreté Nucléaire · FRUniversity of California, San Francisco · USBenemérita Universidad Autónoma de Puebla · MXCentre National de la Recherche Scientifique · FRMassachusetts General Hospital · US

Funding

TOPAS - nBio, a Monte Carlo tool for radiation biology researchR01CA187003 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI SCHUEMANN, JAN PATRICK OSCAR · 2015 to 2024
$4.8M
NCI NIH HHS R01 CA187003
6 · The paper itself

Abstract

The chemical stage of the Monte Carlo track-structure (MCTS) code Geant4-DNA was extended for its use in DNA strand break (SB) simulations and compared against published experimental data. Geant4-DNA simulations were performed using pUC19 plasmids (2686 base pairs) in a buffered solution of DMSO irradiated by

Indexed as

Dimethyl SulfoxideDNA DamageComputer SimulationDNAMonte Carlo MethodNucleic Acid ConformationPlasmidsDimethyl SulfoxideDNADNA damagegeant4-DNAplasmidradiation chemistrysimulationtrack-structure

Identifiers

PMID34787099
PMCPMC9765991
OpenAlexW3213351363

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.