ArticleeLife2021
Arginine-vasopressin mediates counter-regulatory glucagon release and is diminished in type 1 diabetes.
Open access · goldAbstract read
In one paragraph
Article in eLife, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
6.3field-weighted citation impact, top 3% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 41 citations in OpenAlex.
- Trial
- The role of supraoptic hypothalamic arginine vasopressin neurons in aging-associated water balance and thermoregulatory deficits in male mice.Nature communications · 2026Article
- Prefrontal-medullary circuitry is necessary for sex-specific responses to metabolic stress in rats.Endocrinology · 2026Article
- β-Cell Obligation in α-Cell Glucagon Response to Low Glucose.Research square · 2026Article
- Prefrontal-medullary circuitry is necessary for sex-specific responses to metabolic stress in rats.bioRxiv : the preprint server for biology · 2026Article
- Neural Regulation of Blood Glucose in Acute Stress: A Report on Research Supported by Pathway to Stop Diabetes.Diabetes · 2026Review
- Antecedent hypoglycaemia impairs glucagon secretion by enhancing somatostatin-mediated negative feedback control.Nature metabolism · 2026Article
- Localized GLP1 receptor pre-internalization directs pancreatic alpha cell to beta cell communication.Cell metabolism · 2025Article
- Brain amino acid sensing for organismal amino acid homeostasis.Open biology · 2025Review
- The Impact of Hydration on Metabolic Outcomes: From Arginine-Vasopressin Signaling to Clinical Implications.Medicina (Kaunas, Lithuania) · 2025Review
- Dehydration-induced AVP stimulates glucagon release and ketogenesis.American journal of physiology. Endocrinology and metabolism · 2025Article
- Central and peripheral neural circuits regulating glucose homeostasis.npj biomedical innovations · 2025Review
- Molecular Interaction Between Vasopressin and Insulin in Regulation of Metabolism: Impact on Cardiovascular and Metabolic Diseases.International journal of molecular sciences · 2024Review
- Aldosterone-induced salt appetite requires HSD2 neurons.JCI insight · 2024Article
- V1bR enhances glucose-stimulated insulin secretion by paracrine production of glucagon which activates GLP-1 receptor.Cell & bioscience · 2024Article
- Higher beta-hydroxybutyrate ketone levels associated with a slower kidney function decline in ADPKD.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2024Observational
- Validity of mental and physical stress models.Neuroscience and biobehavioral reviews · 2024Review
- Disrupted hypothalamic transcriptomics and proteomics in a mouse model of type 2 diabetes exposed to recurrent hypoglycaemia.Diabetologia · 2024Article
- Interplay of Angiotensin Peptides, Vasopressin, and Insulin in the Heart: Experimental and Clinical Evidence of Altered Interactions in Obesity and Diabetes Mellitus.International journal of molecular sciences · 2024Review
- Donor noradrenaline use is associated with better allograft survival in recipients of pancreas transplantation.Annals of the Royal College of Surgeons of England · 2024Article
Corrections and comments
- Commented on by
Authors and funding
24 authors at 8 institutions in 5 countries.
Angela KimDivision of Endocrinology, Diabetes, and Metabolism, Beth Israel Deaconess Medical Center, Boston, United States.ORCID 0000-0002-9475-0798
Jakob G KnudsenOxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom.
Joseph C MadaraDivision of Endocrinology, Diabetes, and Metabolism, Beth Israel Deaconess Medical Center, Boston, United States.
Anna BenrickMetabolic Research Unit, Institute of Neuroscience and Physiology, Sahlgrenska Academy at University of Gothenburg, Göteborg, Sweden.ORCID 0000-0003-4616-6789
Thomas G HillOxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom.
Lina Abdul KadirOxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom.ORCID 0000-0001-6440-1282
Joely A KellardOxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom.ORCID 0000-0002-0822-1460
Lisa MellanderMetabolic Research Unit, Institute of Neuroscience and Physiology, Sahlgrenska Academy at University of Gothenburg, Göteborg, Sweden.
Caroline MirandaMetabolic Research Unit, Institute of Neuroscience and Physiology, Sahlgrenska Academy at University of Gothenburg, Göteborg, Sweden.
Haopeng LinAlberta Diabetes Institute, Li Ka Shing Centre for Health Research Innovation, Edmonton, Canada.
Timothy JamesDepartment of Clinical Biochemistry, John Radcliffe, Oxford NHS Trust, Oxford, United Kingdom.
Kinga SubaSection of Cell Biology and Functional Genomics, Department of Metabolism, Digestion and Reproduction, Imperial College London, London, United Kingdom.
Aliya F SpigelmanAlberta Diabetes Institute, Li Ka Shing Centre for Health Research Innovation, Edmonton, Canada.
Yanling WuMetabolic Research Unit, Institute of Neuroscience and Physiology, Sahlgrenska Academy at University of Gothenburg, Göteborg, Sweden.
Patrick E MacDonaldAlberta Diabetes Institute, Li Ka Shing Centre for Health Research Innovation, Edmonton, Canada.
Ingrid Wernstedt AsterholmMetabolic Research Unit, Institute of Neuroscience and Physiology, Sahlgrenska Academy at University of Gothenburg, Göteborg, Sweden.ORCID 0000-0002-0755-5784
Tore MagnussenCenter for Clinical Metabolic Research, Gentofte Hospital, Hellerup, Denmark.
Mikkel ChristensenCenter for Clinical Metabolic Research, Gentofte Hospital, Hellerup, Denmark.
Tina VilsbøllCenter for Clinical Metabolic Research, Gentofte Hospital, Hellerup, Denmark.
Victoria SalemSection of Cell Biology and Functional Genomics, Department of Metabolism, Digestion and Reproduction, Imperial College London, London, United Kingdom.
Filip K KnopCenter for Clinical Metabolic Research, Gentofte Hospital, Hellerup, Denmark.
Patrik RorsmanOxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom.ORCID 0000-0001-7578-0767
Bradford B LowellDivision of Endocrinology, Diabetes, and Metabolism, Beth Israel Deaconess Medical Center, Boston, United States.ORCID 0000-0002-0436-3760
Linford Jb BriantOxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom.ORCID 0000-0003-3619-3177
University of Gothenburg · SEUniversity of Oxford · GBUniversity of Copenhagen · DKHarvard University · USImperial College London · GBGentofte Hospital · DKHadassah Medical Center · ILJohn Radcliffe Hospital · GB
Funding
Transgenic CoreP30DK057521 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI KAHN, BARBARA B. · 2000 to 2019
$31.4MTransgenic CoreP30DK046200 · NIDDK · TUFTS MEDICAL CENTER · PI CORKEY, BARBARA E. · 1992 to 2021
$25.0MThe routing of hunger/satiety information by the parabrachial nucleus (PBN)R01DK075632 · NIDDK · BETH ISRAEL DEACONESS MEDICAL CENTER · PI BRADFORD B LOWELL · 2006 to 2026
$8.1MAGRP NEURONS. NMDARs, Spines, Source of Excitatory Input and Downstream EffectorsR01DK096010 · NIDDK · BETH ISRAEL DEACONESS MEDICAL CENTER · PI LOWELL, BRADFORD B · 2012 to 2024
$7.2MNeurocircuitry Underlying Leptin Regulation of Energy BalanceR01DK089044 · NIDDK · BETH ISRAEL DEACONESS MEDICAL CENTER · PI LOWELL, BRADFORD B · 2010 to 2023
$6.0MGlutamatergic Neurons in the Arcuate Nucleus (ARC) and Regulation of SatietyR01DK111401 · NIDDK · BETH ISRAEL DEACONESS MEDICAL CENTER · PI LOWELL, BRADFORD B · 2016 to 2020
$2.2MIdentifying the Neural circuit for presystemic control of vasopressin releaseF31DK109575 · NIDDK · HARVARD MEDICAL SCHOOL · PI KIM, ANGELA · 2017 to 2019
$101kMedical Research Council G0801995Medical Research Council MR/V011979/1NIDDK NIH HHS F31 DK109575NIDDK NIH HHS P30 DK046200NIDDK NIH HHS P30 DK057521NIDDK NIH HHS R01 DK075632NIDDK NIH HHS R01 DK089044NIDDK NIH HHS R01 DK096010NIDDK NIH HHS R01 DK111401NIH HHS F31 DK109575NIH HHS P30 DK046200NIH HHS P30 DK057521NIH HHS R01 DK075632NIH HHS R01 DK089044NIH HHS R01 DK111401Wellcome Trust 095531Wellcome Trust 095531/Z/11/ZWellcome Trust 201325/Z/16/ZWellcome Trust 884655
Abstract
Insulin-induced hypoglycemia is a major treatment barrier in type-1 diabetes (T1D). Accordingly, it is important that we understand the mechanisms regulating the circulating levels of glucagon. Varying glucose over the range of concentrations that occur physiologically between the fed and fuel-deprived states (8 to 4 mM) has no significant effect on glucagon secretion in the perfused mouse pancreas or in isolated mouse islets (in vitro), and yet associates with dramatic increases in plasma glucagon. The identity of the systemic factor(s) that elevates circulating glucagon remains unknown. Here, we show that arginine-vasopressin (AVP), secreted from the posterior pituitary, stimulates glucagon secretion. Alpha-cells express high levels of the vasopressin 1b receptor (V1bR) gene (
Indexed as
AdultAnimalsArginine VasopressinDiabetes Mellitus, Type 1FemaleGlucagonHumansMaleMiceYoung AdultArginine VasopressinGlucagonbrain glucose sensingcell biologycounter-regulationglucagonhumanisletsmouseneurosciencevasopressin
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.