ArticleProceedings of the National Academy of Sciences of the United States of America1987
Isolation and characterization of cDNA clones for human erythrocyte beta-spectrin.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1987. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 41 citations in OpenAlex.
- A novel isoform of beta-spectrin II localizes to cerebellar Purkinje-cell bodies and interacts with neurofibromatosis type 2 gene product schwannomin.Journal of molecular neuroscience : MN · 2001Article
- Detection and expression of a cDNA clone that encodes a polypeptide containing two inhibitory domains of human calpastatin and its recognition by rheumatoid arthritis sera.The Journal of clinical investigation · 1995Article
- A TaqI polymorphism in the human erythroid beta spectrin gene.Human genetics · 1995Article
- Four different mutations in codon 28 of alpha spectrin are associated with structurally and functionally abnormal spectrin alpha I/74 in hereditary elliptocytosis.The Journal of clinical investigation · 1991Article
- Cloning and chromosomal localization of the human cytoskeletal alpha-actinin gene reveals linkage to the beta-spectrin gene.American journal of human genetics · 1990Article
- Krabbe disease locus mapped to chromosome 14 by genetic linkage.American journal of human genetics · 1990Article
- Sequence similarity of the amino-terminal domain of Drosophila beta spectrin to alpha actinin and dystrophin.The Journal of cell biology · 1989Article
- Human chromosome 8.Journal of medical genetics · 1988Review
- Chromosomal location of three spectrin genes: relationship to the inherited hemolytic anemias of mouse and man.Proceedings of the National Academy of Sciences of the United States of America · 1988Article
- Unequal synthesis and differential degradation of alpha and beta spectrin during murine erythroid differentiation.The Journal of cell biology · 1988Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
Spectrin is an important structural component of the membrane skeleton that underlies and supports the erythrocyte plasma membrane. It is composed of nonidentical alpha (Mr 240,000) and beta (Mr 220,000) subunits, each of which contains multiple homologous 106-amino acid segments. We report here the isolation and characterization of a human erythroid-specific beta-spectrin cDNA clone that encodes parts of the beta-9 through beta-12 repeat segments. This cDNA was used as a hybridization probe to assign the beta-spectrin gene to human chromosome 14 and to begin molecular analysis of the gene and its mRNA transcripts. RNA transfer blot analysis showed that the reticulocyte beta-spectrin mRNA is 7.8 kilobases in length. Southern blot analysis of genomic DNA revealed the presence of restriction fragment length polymorphisms (RFLPs) within the beta-spectrin gene locus. The isolation of human spectrin cDNA probes and the identification of closely linked RFLPs will facilitate analysis of mutant spectrin genes causing congenital hemolytic anemias associated with quantitative and qualitative spectrin abnormalities.
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