ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2022
The association of motoric cognitive risk with incident dementia and neuroimaging characteristics: The Atherosclerosis Risk in Communities Study.
Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 2 syntheses or guidelines pooled it, 32 citations in OpenAlex.
- Association of motoric cognitive risk syndrome with depression in older adults: a meta-analysis and systematic review of cross-sectional and cohort studies.BMC geriatrics · 2024Pooled it
- Early detection of diseases causing dementia using digital navigation and gait measures: A systematic review of evidence.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Pooled it
- Novel genetic profile linked to cognitive decline in Hispanics/Latinos.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Age-friendly environments and incident motoric cognitive risk syndrome in older adults: A prospective cohort study.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- How physical activity influences motoric cognitive risk syndrome in older adults.BMC geriatrics · 2025Article
- Greater White Matter Hyperintensities and More Severe Cognitive Dysfunction in Mild Cognitive Impairment With Motoric Cognitive Risk Syndrome.Journal of Korean medical science · 2025Article
- Plasma Proteins Associated with the Mediterranean-Dietary Approaches to Stop Hypertension Intervention for Neurodegenerative Delay (MIND) Diet and Incident Dementia.The Journal of nutrition · 2025Article
- Motoric Cognitive Risk Syndrome and Risk of Cardiovascular Disease: A Population-Based Study.The journals of gerontology. Series A, Biological sciences and medical sciences · 2025Article
- Association between high plasma p-tau181 level and gait changes in patients with mild cognitive impairment.Scientific reports · 2025Article
- Clinical, biological, and neuroimaging profiles for motoric cognitive risk syndrome in older adults: The MIND-China study.Journal of internal medicine · 2025Article
- Mapping the neural substrate of high dual-task gait cost in older adults across the cognitive spectrum.Brain structure & function · 2025Article
- Family history of dementia and brain health in childhood and middle age: a prospective community-based study.European journal of epidemiology · 2024Article
- Multi-trajectories in different domains of social supports and subjective motoric cognitive risk syndrome: a 16-year group-based multi-trajectory analysis.The journal of nutrition, health & aging · 2024Article
- Article
- Social frailty and the incidence of motoric cognitive risk syndrome in older adults.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- Distinct Patterns of Brain Atrophy in Amnestic Mild Cognitive Impairment and Motoric Cognitive Risk Syndromes.Neuro-degenerative diseases · 2024Article
- Motoric Cognitive Risk and Incident Dementia in Older Adults.JAMA network open · 2023Article
- Potential Imaging Biomarkers of Cognitive Frailty.Annals of geriatric medicine and research · 2023Article
- Motoric cognitive risk syndrome trajectories and incident dementia over 10 years.Cerebral circulation - cognition and behavior · 2023Article
- Testosterone, cognitive decline and dementia in ageing men.Reviews in endocrine & metabolic disorders · 2022Review
Corrections and comments
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Authors and funding
12 authors at 6 institutions in 1 country.
Funding
Abstract
introductionMotoric cognitive risk (MCR), a clinical syndrome characterized by slow gait speed and subjective cognitive complaints, has been associated with dementia risk. The neuropathological features underlying MCR remain poorly understood.
methodsThe Atherosclerosis Risk in Communities (ARIC) community-based cohort study classified participants using standardized criteria as MCR+/- and mild cognitive impairment (MCI)+/- at study baseline (2011-2013). We examined the 5-year dementia risk and baseline brain structural/molecular abnormalities associated with MCR+ and MCI+ status.
resultsOf 5023 nondemented participants included, 204 were MCR+ and 1030 were MCI+. Both MCR+ and MCI+ participants demonstrated increased dementia risk. The pattern of structural brain abnormalities associated with MCR+ differed from that of MCI+. Whereas MCI+ was associated with comparatively smaller volumes in brain regions vulnerable to Alzheimer's disease pathology, MCR+ status was associated with smaller volumes in frontoparietal regions and greater white matter abnormalities. DISCUSSION: MCR may represent a predementia syndrome characterized by prominent white matter abnormalities and frontoparietal atrophy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.