Evidence map›Paper›PMID 34786700›Full record

ArticleChild development2021

Early social communication development in infants with autism spectrum disorder.

Jessica Bradshaw, Courtney McCracken, Moira Pileggi, Natalie Brane, Abigail Delehanty, Taylor Day, Alexis Federico, Cheryl Klaiman, Celine Saulnier, Ami Klin and 1 more

Abstract read
In one paragraph

Article in Child development, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Family Outcomes of a Community-Based Trial of Project ImPACT.Behavioral sciences (Basel, Switzerland) · 2025
    Article
  10. Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Neonatal autonomic regulation as a predictor of autism symptoms in very preterm infants.Journal of perinatology : official journal of the California Perinatal Association · 2025
    Article
  17. Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Jessica BradshawUniversity of South Carolina, Columbia, South Carolina, USA.ORCID 0000-0003-3003-3738
Courtney McCrackenEmory University School of Medicine, Atlanta, Georgia, USA.
Moira PileggiMarcus Autism Center, Children's Healthcare of Atlanta, Atlanta, Georgia, USA.
Natalie BraneMarcus Autism Center, Children's Healthcare of Atlanta, Atlanta, Georgia, USA.
Abigail DelehantyJohn G. Rangos, Sr. School of Health Sciences, Duquesne University, Pittsburgh, Pennsylvania, USA.
Taylor DayDepartment of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
Alexis FedericoUniversity of South Carolina, Columbia, South Carolina, USA.
Cheryl KlaimanEmory University School of Medicine, Atlanta, Georgia, USA.
Celine SaulnierEmory University School of Medicine, Atlanta, Georgia, USA.
Ami KlinEmory University School of Medicine, Atlanta, Georgia, USA.
Amy WetherbyAutism Institute, Florida State University, Tallahassee, Florida, USA.

Funding

The ontogeny of social vocal engagement and its derailment in autismP50MH100029 · NIMH · EMORY UNIVERSITY · PI WETHERBY, AMY M · 2012 to 2021
$20.1M
Biomedical-Behavioral Interface: Prevention and Developmental Sciences TrainingT32GM081740 · NIGMS · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · PI PRINZ, RONALD J · 2008 to 2022
$4.5M
Smart Early Screening for Autism and Communication Disorders in Primary CareR01HD078410 · NICHD · FLORIDA STATE UNIVERSITY · PI WETHERBY, AMY M · 2014 to 2018
$2.5M
Heart Defined Attention in Infancy: Predicting Social Communication and ASD SymptomologyK23MH120476 · NIMH · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · PI BRADSHAW, JESSICA · 2019 to 2023
$939k
Neurobehavioral Determinants of Social Communication and Language Impairments in at - Risk InfantsR21DC017252 · NIDCD · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · PI BRADSHAW, JESSICA · 2020 to 2022
$427k
Integrated Treatment of Persons with Co-Occurring HCV and Alcohol Use/AbuseR21AA017252 · NIAAA · DUKE UNIVERSITY · PI MUIR, ANDREW J. · 2008 to 2009
$410k
Georgia Research AllianceJoseph B. Whitehead FoundationMarcus FoundationNIAAA NIH HHS R21 AA017252NICHD NIH HHS R01 HD078410NIDCD NIH HHS R21 DC017252NIGMS NIH HHS T32 GM081740NIMH NIH HHS K23 MH120476NIMH NIH HHS P50 MH100029Office of the Vice President for Research at the University of South Carolina ASPIRE-I
6 · The paper itself

Abstract

Social-communication differences are a robust and defining feature of autism spectrum disorder (ASD) but identifying early points of divergence in infancy has been a challenge. The current study examines social communication in 9- to 12-month-old infants who develop ASD (N = 30; 23% female; 70% white) compared to typically developing (TD) infants (N = 94, 38% female; 88% white). Results demonstrate that infants later diagnosed with ASD were already exhibiting fewer social-communication skills using eye gaze, facial expression, gestures, and sounds at 9 months (effect size: 0.42-0.89). Moreover, three unique patterns of change across distinct social-communication skills were observed within the ASD group. This study documents that observable social-communication differences for infants with ASD are unfolding by 9 months, pointing to a critical window for targeted intervention.

Indexed as

Autism Spectrum DisorderCommunicationFemaleFixation, OcularGesturesHumansInfantMale

Identifiers

PMID34786700
PMCPMC8935345

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.