Evidence map›Paper›PMID 34786666›Full record

SynthesisBrain imaging and behavior2022

A systematic review of resting-state and task-based fmri in juvenile myoclonic epilepsy.

Hossein Sanjari Moghaddam, Ali Sanjari Moghaddam, Alireza Hasanzadeh, Zahra Sanatian, Amirreza Mafi, Mohammad Hadi Aarabi, Mohammadmehdi Samimi, Vajiheh Aghamollaii, Taha Gholipour, Abbas Tafakhori

Abstract readSystematic Review
PubMed Publisher
In one paragraph

Synthesis in Brain imaging and behavior, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.9field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Article
  3. The network neuropsychology of juvenile myoclonic epilepsy.Cortex; a journal devoted to the study of the nervous system and behavior · 2025
    Article
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 3 countries.

Hossein Sanjari MoghaddamIranian Center of Neurological Research (ICNR), Tehran University of Medical Sciences, Tehran, Iran.
Ali Sanjari MoghaddamDepartment of Medicine, Duke University Medical Center, Durham, NC, USA.
Alireza HasanzadehIranian Center of Neurological Research (ICNR), Tehran University of Medical Sciences, Tehran, Iran.
Zahra SanatianIranian Center of Neurological Research (ICNR), Tehran University of Medical Sciences, Tehran, Iran.
Amirreza MafiIranian Center of Neurological Research (ICNR), Tehran University of Medical Sciences, Tehran, Iran.
Mohammad Hadi AarabiDepartment of Neuroscience (DNS), Padova Neuroscience Center, University of Padova, Padua, Italy. Mohammadhadiarabi@gmail.com.ORCID http://orcid.org/0000-0002-5550-9782
Mohammadmehdi SamimiIranian Center of Neurological Research (ICNR), Tehran University of Medical Sciences, Tehran, Iran.
Vajiheh AghamollaiiIranian Center of Neurological Research (ICNR), Tehran University of Medical Sciences, Tehran, Iran.
Taha GholipourDepartment of Neurology, The George Washington University Epilepsy Center, Washington, DC, USA.
Abbas TafakhoriIranian Center of Neurological Research (ICNR), Tehran University of Medical Sciences, Tehran, Iran.
Tehran University of Medical Sciences · IRDuke Medical Center · USGeorge Washington University · USUniversity of Padua · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Functional neuroimaging modalities have enhanced our understanding of juvenile myoclonic epilepsy (JME) underlying neural mechanisms. Due to its non-invasive, sensitive and analytical nature, functional magnetic resonance imaging (fMRI) provides valuable insights into relevant functional brain networks and their segregation and integration properties. We systematically reviewed the contribution of resting-state and task-based fMRI to the current understanding of the pathophysiology and the patterns of seizure propagation in JME Altogether, despite some discrepancies, functional findings suggest that corticothalamo-striato-cerebellar network along with default-mode network and salience network are the most affected networks in patients with JME. However, further studies are required to investigate the association between JME's main deficiencies, e.g., motor and cognitive deficiencies and fMRI findings. Moreover, simultaneous electroencephalography-fMRI (EEG-fMRI) studies indicate that alterations of these networks play a role in seizure modulation but fall short of identifying a causal relationship between altered functional properties and seizure propagation. This review highlights the complex pathophysiology of JME, which necessitates the design of more personalized diagnostic and therapeutic strategies in this group.

Indexed as

Myoclonic Epilepsy, JuvenileBrainElectroencephalographyHumansMagnetic Resonance ImagingSeizuresFunctional magnetic resonance imagingJuvenile myoclonic epilepsyResting-state fMRITask-based fMRI

Identifiers

PMID34786666
OpenAlexW3214506330

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.