ArticleMolecular genetics and genomics : MGG2022
Circular RNA screening identifies circMYLK4 as a regulator of fast/slow myofibers in porcine skeletal muscles.
Article in Molecular genetics and genomics : MGG, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 19 citations in OpenAlex.
- A circRNA-miRNA-mRNA network potentially regulates skeletal muscle adaptation to hypoxia in Tibetan sheep.BMC genomics · 2026Article
- A Novel tRF-Lys-TTT-012 in Qingyu Pigs Mediates the Conversion of Muscle Fibers from Fast-Twitch to Slow-Twitch Type.Animals : an open access journal from MDPI · 2025Article
- Circ-06958 Is Involved in Meat Quality by Regulating Cell Proliferation Through miR-31-5p/AK4 Axis in Pigs.Cells · 2025Article
- Research Progress on the Regulating Factors of Muscle Fiber Heterogeneity in Livestock: A Review.Animals : an open access journal from MDPI · 2024Review
- Identification of different myofiber types in pigs muscles and construction of regulatory networks.BMC genomics · 2024Article
- Transcriptome analysis reveals the regulatory mechanism of myofiber development in male and female black Muscovy duck at different ages.Frontiers in veterinary science · 2024Article
- Recent Progress on Circular RNAs in the Development of Skeletal Muscle and Adipose Tissues of Farm Animals.Biomolecules · 2023Review
- Integrated analysis of circRNA, lncRNA, miRNA and mRNA to reveal the ceRNA regulatory network of postnatal skeletal muscle development in Ningxiang pig.Frontiers in cell and developmental biology · 2023Article
- Molecular mechanisms underlying the impact of muscle fiber types on meat quality in livestock and poultry.Frontiers in veterinary science · 2023Review
- The Role of Gut Microbiota in the Skeletal Muscle Development and Fat Deposition in Pigs.Antibiotics (Basel, Switzerland) · 2022Article
- Identification and characterization of circular RNAs in Longissimus dorsi muscle tissue from two goat breeds using RNA-Seq.Molecular genetics and genomics : MGG · 2022Article
- Identification and characterization of circRNAs related to meat quality during embryonic development of the longissimus dorsi muscle in two pig breeds.Frontiers in genetics · 2022Article
Corrections and comments
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Authors and funding
11 authors at 2 institutions in 1 country.
Funding
Abstract
The type of myofiber is related to the quality of meat. The slow oxidized myofiber helps to increase the tenderness and juiciness of muscle. Numerous studies have shown that circRNA plays a key role in skeletal muscle development. However, the role of circRNA in porcine skeletal myofiber types is unclear. In this study, we performed high-throughput RNA sequencing to study the differential expression of circRNA in the longissimus dorsi and the soleus muscle. A total of 40,757 circRNAs were identified, of which 181 were significantly different. Interestingly, some circRNAs were involved in metabolism pathways, AMPK, FoxO, and PI3K-Akt signaling pathways. Besides, we focused on a novel circRNA-circMYLK4. By injecting circMYLK4-AAV into piglets, we found that circMYLK4 significantly increased the mRNA and protein levels of the slow muscle marker genes. In summary, our study laid an essential foundation for further research of circRNA in myofiber type conversion and higher meat quality.
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Registered trials
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