Evidence map›Paper›PMID 34786613›Full record

ArticleInternational journal of bipolar disorders2021

The German research consortium for the study of bipolar disorder (BipoLife): a magnetic resonance imaging study protocol.

Christoph Vogelbacher, Jens Sommer, Verena Schuster, Miriam H A Bopp, Irina Falkenberg, Philipp S Ritter, Felix Bermpohl, Catherine Hindi Attar, Lisa Rauer, Karolin E Einenkel and 14 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of bipolar disorders, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors.

Christoph VogelbacherDepartment of Psychiatry and Psychotherapy, University of Marburg, Rudolf-Bultmann-Straße 8, 35039, Marburg, Germany. vogelbac@staff.uni-marburg.de.ORCID http://orcid.org/0000-0002-3191-1400
Jens SommerCenter for Mind, Brain, and Behavior (CMBB), Universities of Marburg and Gießen, Marburg, Germany.
Verena SchusterDepartment of Psychiatry and Psychotherapy, University of Marburg, Rudolf-Bultmann-Straße 8, 35039, Marburg, Germany.
Miriam H A BoppDepartment of Psychiatry and Psychotherapy, University of Marburg, Rudolf-Bultmann-Straße 8, 35039, Marburg, Germany.
Irina FalkenbergDepartment of Psychiatry and Psychotherapy, University of Marburg, Rudolf-Bultmann-Straße 8, 35039, Marburg, Germany.
Philipp S RitterDepartment of Psychiatry and Psychotherapy, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
Felix BermpohlCharité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Department of Psychiatry and Psychotherapy, Charité at St. Hedwig-Krankenhaus, Berlin, Germany.
Catherine Hindi AttarCharité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Department of Psychiatry and Psychotherapy, Charité at St. Hedwig-Krankenhaus, Berlin, Germany.
Lisa RauerSection for Experimental Psychopathology and Neuroimaging, Department of General Psychiatry, Heidelberg University, Heidelberg, Germany.
Karolin E EinenkelSection for Experimental Psychopathology and Neuroimaging, Department of General Psychiatry, Heidelberg University, Heidelberg, Germany.
Jens TreutleinSection for Experimental Psychopathology and Neuroimaging, Department of General Psychiatry, Heidelberg University, Heidelberg, Germany.
Oliver GruberSection for Experimental Psychopathology and Neuroimaging, Department of General Psychiatry, Heidelberg University, Heidelberg, Germany.
Georg JuckelDepartment of Psychiatry, Psychotherapy and Preventive Medicine, LWL University Hospital, Ruhr University Bochum, Bochum, Germany.
Vera FlasbeckDepartment of Psychiatry, Psychotherapy and Preventive Medicine, LWL University Hospital, Ruhr University Bochum, Bochum, Germany.
Christoph MulertCenter for Mind, Brain, and Behavior (CMBB), Universities of Marburg and Gießen, Marburg, Germany.
Martin HautzingerDepartment of Psychology Clinical Psychology and Psychotherapy, Eberhard Karls University, Tübingen, Germany.
Andrea PfennigDepartment of Psychiatry and Psychotherapy, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
Silke MaturaDepartment of Psychiatry, Psychosomatic Medicine and Psychotherapy, University Hospital Frankfurt, Frankfurt, Germany.
Andreas ReifDepartment of Psychiatry, Psychosomatic Medicine and Psychotherapy, University Hospital Frankfurt, Frankfurt, Germany.
Dominik GrotegerdDepartment of Psychiatry, University of Münster, Münster, Germany.
Udo DannlowskiDepartment of Psychiatry, University of Münster, Münster, Germany.
Tilo KircherDepartment of Psychiatry and Psychotherapy, University of Marburg, Rudolf-Bultmann-Straße 8, 35039, Marburg, Germany.
Michael BauerDepartment of Psychiatry and Psychotherapy, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
Andreas JansenDepartment of Psychiatry and Psychotherapy, University of Marburg, Rudolf-Bultmann-Straße 8, 35039, Marburg, Germany.

Funding

Bundesministerium für Bildung und Forschung 01EE1404A-HBundesministerium für Bildung und Forschung 01EE1404E
6 · The paper itself

Abstract

backgroundBipolar disorder is one of the most severe mental disorders. Its chronic course is associated with high rates of morbidity and mortality, a high risk of suicide and poor social and occupational outcomes. Despite the great advances over the last decades in understanding mental disorders, the mechanisms underlying bipolar disorder at the neural network level still remain elusive. This has severe consequences for clinical practice, for instance by inadequate diagnoses or delayed treatments. The German research consortium BipoLife aims to shed light on the mechanisms underlying bipolar disorders. It was established in 2015 and incorporates ten university hospitals across Germany. Its research projects focus in particular on individuals at high risk of bipolar disorder, young patients in the early stages of the disease and patients with an unstable highly relapsing course and/or with acute suicidal ideation.

methodsFunctional and structural magnetic resonance imaging (MRI) data was acquired across nine sites within three different studies. Obtaining neuroimaging data in a multicenter setting requires among others the harmonization of the acquisition protocol, the standardization of paradigms and the implementation of regular quality control procedures. The present article outlines the MRI imaging protocols, the acquisition parameters, the imaging paradigms, the neuroimaging quality assessment procedures and the number of recruited subjects. DISCUSSION: The careful implementation of a MRI study protocol as well as the adherence to well-defined quality assessment procedures is one key benchmark in the evaluation of the overall quality of large-scale multicenter imaging studies. This article contributes to the BipoLife project by outlining the rationale and the design of the MRI study protocol. It helps to set the necessary standards for follow-up analyses and provides the technical details for an in-depth understanding of follow-up publications.

Indexed as

Bipolar disorderBipoLifeEarly interventionEarly recognitionfMRIMajor depressionMRI quality assuranceMulticenter study

Identifiers

PMID34786613
PMCPMC8595454

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.