ReviewThe Analyst2021
Compositional assessment of bone by Raman spectroscopy.
Review in The Analyst, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
45 citing papers in PubMed, 75 citations in OpenAlex.
- Bone microarchitecture and material properties decline differently across midlife for male and female F344 × BN F1 rats.bioRxiv : the preprint server for biology · 2026Article
- Article
- Impaired organic and mineral extracellular matrix composition in early-onset osteoporosis.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2026Article
- Predicting wrist osteoporosis from excised human finger bones using spatially offset Raman spectroscopy - a cadaveric study.Biomedical optics express · 2026Article
- Modulating silver diamine fluoride chemical derivatives by solid-binding peptides.Frontiers in bioengineering and biotechnology · 2026Article
- Raman spectroscopic fingerprinting uncovers a multi-scale structural-mechanical-transcriptomic coupling landscape in osteoporosis.Frontiers in endocrinology · 2026Article
- Label-free molecular profiling of cancer using Raman spectroscopy: from fundamentals to clinical applications.Frontiers in oncology · 2026Review
- Bone formation niche dysfunction in osteoporosis: insights from single-cell and spatial transcriptomic studies.Frontiers in endocrinology · 2026Review
- Composites Derived from Aluminium-Modified Biphasic Calcium-Phosphate for Bone Regeneration.Biomimetics (Basel, Switzerland) · 2025Article
- Article
- Glycoxidation of the bone matrix modulates mineralization.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2025Article
- Prediction of biomechanical properties of ex vivo human femoral cortical bone using Raman spectroscopy and machine learning algorithms.Bone reports · 2025Article
- Potential preventive effects of angiotensin-(1-7) on bone matrix quality in diabetic rats through modulation of the organic matrix.Joint diseases and related surgery · 2025Article
- Short-term high-fat diet impacts bone material properties and metabolism for adult and aged C57BL/6JN mice.Communications biology · 2025Article
- Dual-modality SEM-Raman smart scanning for fast hyperspectral Raman micro-imaging - application to bones.Biomedical optics express · 2025Article
- Article
- Optimizing number of Raman spectra using an artificial neural network guided Monte Carlo simulation approach to analyze human cortical bone.Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy · 2025Article
- Long-duration type 1 diabetes is associated with deficient cortical bone mechanical behavior and altered matrix composition in human femoral bone.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2024Article
- Zebrafish Models for Skeletal and Extraskeletal Osteogenesis Imperfecta Features: Unveiling Pathophysiology and Paving the Way for Drug Discovery.Calcified tissue international · 2024Review
- Raman Handheld Versus Microscopic Spectroscopy for Estimating the Post-Mortem Interval of Human Bones: A Comparative Pilot Study.Bioengineering (Basel, Switzerland) · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
Abstract
Raman spectroscopy (RS) is used to analyze the physiochemical properties of bone because it is non-destructive and requires minimal sample preparation. With over two decades of research involving measurements of mineral-to-matrix ratio, type-B carbonate substitution, crystallinity, and other compositional characteristics of the bone matrix by RS, there are multiple methods to acquire Raman signals from bone, to process those signals, and to determine peak ratios including sub-peak ratios as well as the full-width at half maximum of the most prominent Raman peak, which is nu1 phosphate (ν
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.