Evidence map›Paper›PMID 34786451›Full record

ArticleInternational journal of cardiology. Heart & vasculature2021

Left ventricular vortex analysis by high-frame rate blood speckle tracking echocardiography in healthy children and in congenital heart disease.

Pietro Marchese, Massimiliano Cantinotti, Jef Van den Eynde, Nadia Assanta, Eliana Franchi, Vitali Pak, Giuseppe Santoro, Martin Koestenberger, Shelby Kutty

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of cardiology. Heart & vasculature, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
2.4field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 21 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Review
  8. Review
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 4 countries.

Pietro MarcheseFondazione G. Monasterio CNR-Regione Toscana, Massa and Pisa, Italy.
Massimiliano CantinottiFondazione G. Monasterio CNR-Regione Toscana, Massa and Pisa, Italy.
Jef Van den EyndeTaussig Heart Center, Department of Pediatrics, Johns Hopkins Hospital, Baltimore, MD, USA.
Nadia AssantaFondazione G. Monasterio CNR-Regione Toscana, Massa and Pisa, Italy.
Eliana FranchiFondazione G. Monasterio CNR-Regione Toscana, Massa and Pisa, Italy.
Vitali PakFondazione G. Monasterio CNR-Regione Toscana, Massa and Pisa, Italy.
Giuseppe SantoroFondazione G. Monasterio CNR-Regione Toscana, Massa and Pisa, Italy.
Martin KoestenbergerDivision of Pediatric Cardiology, Medical University Graz, Austria.
Shelby KuttyTaussig Heart Center, Department of Pediatrics, Johns Hopkins Hospital, Baltimore, MD, USA.
Fondazione Toscana Gabriele Monasterio · ITJohns Hopkins Hospital · USIstituto di Fisiologia Clinica · ITMedical University of Graz · AT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundHigh-frame rate blood speckle tracking (BST) echocardiography is a new technique for the assessment of intracardiac flow. The purpose of this study was to evaluate the characteristics of left ventricular (LV) vortices in healthy children and in those with congenital heart disease (CHD).

methodsCharacteristics of LV vortices were analyses based on 4-chamber BST images from 118 healthy children (median age 6.84 years, range 0.01-17 years) and 43 children with CHD (median age 0.99 years, range 0.01-14 years). Both groups were compared after propensity matching. Multiple linear regression was used to identify factors that independently influence vortex characteristics.

resultsFeasibility of vortex imaging was 93.7% for healthy children and 95.6% for CHD. After propensity matching, there were no overall significant differences in vortex distance to apex, distance to interventricular septum (IVS), height, width, sphericity index, or area. However, multiple regression analysis revealed significant associations of LV morphology with vortex characteristics. Furthermore, CHD involving LV volume overload and CHD involving LV pressure overload were both associated with vortices localized closer to the IVS.

conclusionsLV vortex analysis using high-frame rate BST echocardiography is feasible in healthy children and in those with CHD. As they are associated with LV morphology and are modified in some types of CHD, vortices might yield diagnostic and prognostic value. Future studies are warranted to establish applications of vortex imaging in the clinical setting.

Indexed as

AV, atrioventricularBlood speckle imagingBMI, body mass indexBpm, beats per minuteBSA, body surface areaBST, blood speckle trackingCHD, congenital heart diseaseCI, correlation indexCongenitalEchocardiographyED, end-diastolicFps, frame per secondHeart defectsICC, intraclass correlation coefficient-i, indexed to BSAIQR, interquartile rangeIVS, interventricular septumLeft ventricleLVEDA, left ventricular end-diastolic areaLVEDD, left ventricular end-diastolic dimensionLVEDV, left ventricular end-diastolic volumeLVEF, left ventricular ejection fractionLVESD, left ventricular end-systolic dimensionLVESV, left ventricular end-systolic volumeLV, left ventricle/ventricularLVOT, left ventricular outflow tractLVPO, CHD involving left ventricle pressure overloadLVSV, left ventricular stroke volumeLVVO, CHD involving left ventricular volume overloadMV, mitral valvePediatricsRVPO, CHD involving right ventricular pressure overloadRVVO, CHD involving right ventricular volume overloadTGA, transposition of the great arteriesVortex imaging

Identifiers

PMID34786451
PMCPMC8579140
OpenAlexW3211181055

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.