ArticleWorld journal of clinical cases2021
Serum calcium, albumin, globulin and matrix metalloproteinase-9 levels in acute cerebral infarction patients.
Article in World journal of clinical cases, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 6 citations in OpenAlex.
- Serum Albumin-Globulin Ratio and Rupture Status of Intracranial Aneurysms: A Case-Control Study.Journal of inflammation research · 2026Article
- Evaluation of (sdLDLc*HCYc)/HDLc ratio in clinical auxiliary diagnosis of primary cerebral infarction.BMC cardiovascular disorders · 2022Article
- The Efficacy of Needle-Warming Moxibustion Combined with Hyperbaric Oxygen Therapy for Ischemic Stroke and Its Effect on Neurological Function.Computational and mathematical methods in medicine · 2022Article
- Prognostic values of serum alkaline phosphatase and globulin levels in patients undergoing intravenous thrombolysis.Frontiers in molecular neuroscience · 2022Article
- Clinical significance of albumin to globulin ratio among patients with stroke-associated pneumonia.Frontiers in nutrition · 2022Article
- A novel nomogram to predict hemorrhagic transformation in ischemic stroke patients after intravenous thrombolysis.Frontiers in neurology · 2022Article
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Authors and funding
7 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundHemorrhagic transformation (HT) is a common complication in patients with cerebral infarction. However, its pathogenesis is poorly understood. The knowledge of factors that may increase risk for HT may help in improving the safety of thrombolytic therapy.
aimTo investigate the predictive value of serum calcium, albumin, globulin and matrix metalloproteinase-9 (MMP-9) levels for HT after intravenous thrombolysis (IVT) in patients with acute cerebral infarction.
methodsFive hundred patients with acute cerebral infarction who received IVT with alteplase within 4.5 h after the onset of disease between January 2018 and January 2021 at our hospital were selected as the study subjects. They were divided into groups based on computed tomography scan results of the brain made within 36 h after thrombolysis. Forty patients with HT were enrolled in an observation group and 460 patients without HT were enrolled in a control group. Serum calcium, albumin, globulin and MMP-9 levels were compared between the two groups. Regression analysis was used to discuss the relationship between these indices and HT.
resultsThe previous history of hypertension, diabetes, atrial fibrillation, cerebrovascular diseases, smoking and alcohol intake were not associated with HT after IVT in patients with acute cerebral infarction (all
conclusionSerum calcium, albumin, globulin and MMP-9 levels are risk factors for HT after IVT in patients with acute cerebral infarction. Moreover, NHISS score can be used as a predictor of post-thrombolytic HT.
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