Evidence map›Paper›PMID 34786369›Full record

ArticleAsia Pacific allergy2021

Evaluation of subcutaneous immunotherapy with birch pollen extract for pollen-food allergy syndrome.

Masaaki Hamada, Masakazu Kagawa, Ichiro Tanaka

Open access · diamondAbstract readCase Reports
In one paragraph

Article in Asia Pacific allergy, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.2field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 11 citations in OpenAlex.

  1. Pollen-Food Allergy Syndrome in China: Current Knowledge and Future Research Needs.International archives of allergy and immunology · 2026
    Review
  2. Review
  3. Article
  4. Article
  5. Subcutaneous Immunotherapy of Food Allergy.Current allergy and asthma reports · 2024
    Review
  6. Review
  7. Article
  8. Article
  9. Asia Pacific allergy · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Masaaki HamadaDepartment of Pediatrics, Yao Municipal Hospital, Yao, Japan.ORCID https://orcid.org/0000-0002-1369-4713
Masakazu KagawaDepartment of Clinical Research Center, Yao Municipal Hospital, Yao, Japan.ORCID https://orcid.org/0000-0003-3436-8842
Ichiro TanakaDepartment of Pediatrics, Yao Municipal Hospital, Yao, Japan.ORCID https://orcid.org/0000-0001-6947-0068
Naga Municipal Hospital · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Some patients with pollen-food allergy syndrome (PFAS) develop systemic symptoms along with oral allergy syndrome upon ingesting processed foods as well as raw fruits and vegetables. This study aimed to investigate the efficacy of subcutaneous immunotherapy with birch pollen extract for patients with PFAS associated with soybean allergy. Subcutaneous immunotherapy with birch pollen extract was introduced in 6 patients with PFAS caused by alder/birch pollen and soybean allergy. An oral food challenge for ingestible amount of soy milk was performed before and 1 year after initiating subcutaneous immunotherapy with birch pollen extract. Before the treatment, the median intake of soy milk was 1.5 mL (interquartile range [IQR], 1-2 mL). One year after the treatment initiation, the median intake of soy milk increased significantly to 150 mL (IQR, 20-200 mL). Systemic reactions occurred in 4 of 6 patients in the rapid escalation phase of the treatment. The results thus suggest that subcutaneous immunotherapy with birch pollen extract could be beneficial for patients with PFAS associated with soybean allergy despite concerns regarding systemic reactions.

Indexed as

Allergen immunotherapyBirch pollenPollen-food allergy syndromeSoybean allergySubcutaneous immunotherapy

Identifiers

PMID34786369
PMCPMC8563098
OpenAlexW3209674279

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.