Evidence map›Paper›PMID 34786328›Full record

ArticleSpatial statistics2022

Modelling the effect of a border closure between Switzerland and Italy on the spatiotemporal spread of COVID-19 in Switzerland.

Mathilde Grimée, Maria Bekker-Nielsen Dunbar, Felix Hofmann, Leonhard Held, SUSPend modelling consortium

Abstract read
In one paragraph

Article in Spatial statistics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Review
  4. Article
  5. Article
  6. Infectious Disease Modelling · 2024
    Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Session 3 of the RSS Special Topic Meeting on Covid-19 Transmission: Replies to the discussion.Journal of the Royal Statistical Society. Series A, (Statistics in Society) · 2022
    Article
  13. Assessing the effect of school closures on the spread of COVID-19 in Zurich.Journal of the Royal Statistical Society. Series A, (Statistics in Society) · 2022
    Article
  14. Extended Bayesian endemic-epidemic models to incorporate mobility data into COVID-19 forecasting.The Canadian journal of statistics = Revue canadienne de statistique · 2022
    Article
  15. Article
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Mathilde GriméeInstitute for Medical Information Processing, Biometry, and Epidemiology, Ludwig-Maximilians-Universität München, Germany.
Maria Bekker-Nielsen DunbarEpidemiology, Biostatistics and Prevention Institute, University of Zurich, Hirschengraben 84, 8001 Zurich, Switzerland.
Felix HofmannEpidemiology, Biostatistics and Prevention Institute, University of Zurich, Hirschengraben 84, 8001 Zurich, Switzerland.
Leonhard HeldEpidemiology, Biostatistics and Prevention Institute, University of Zurich, Hirschengraben 84, 8001 Zurich, Switzerland.
SUSPend modelling consortium

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We present an approach to extend the endemic-epidemic (EE) modelling framework for the analysis of infectious disease data. In its spatiotemporal formulation, spatial dependencies have originally been captured by static neighbourhood matrices. These weight matrices are adjusted over time to reflect changes in spatial connectivity between geographical units. We illustrate this extension by modelling the spread of COVID-19 disease between Swiss and bordering Italian regions in the first wave of the COVID-19 pandemic. The spatial weights are adjusted with data describing the daily changes in population mobility patterns, and indicators of border closures describing the state of travel restrictions since the beginning of the pandemic. These time-dependent weights are used to fit an EE model to the region-stratified time series of new COVID-19 cases. We then adjust the weight matrices to reflect two counterfactual scenarios of border closures and draw counterfactual predictions based on these, to retrospectively assess the usefulness of border closures. Predictions based on a scenario where no closure of the Swiss-Italian border occurred increased the number of cumulative cases in Switzerland by a factor of 2.7 (10th to 90th percentile: 2.2 to 3.6) over the study period. Conversely, a closure of the Swiss-Italian border two weeks earlier than implemented would have resulted in only a 12% (8% to 18%) decrease in the number of cases and merely delayed the epidemic spread by a couple of weeks. Our study provides useful insight into modelling the effect of epidemic countermeasures on the spatiotemporal spread of COVID-19.

Indexed as

Border closureEndemic–epidemic modelHuman mobilityMultivariate time series of countsRespiratory diseaseSpatiotemporal models

Identifiers

PMID34786328
PMCPMC8579705

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.