ReviewCureus2021
Diagnostic Challenges and Management of Fibromyalgia.
Review in Cureus, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
44 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Factors associated with receiving a Functional Disorder diagnostic label: A systematic review.PloS one · 2025Pooled it
- Cluster analysis in fibromyalgia: a systematic review.Rheumatology international · 2024Pooled it
- Fibromyalgia in obstructive sleep apnea-hypopnea syndrome: a systematic review and meta-analysis.Frontiers in physiology · 2024Pooled it
- Comparative Analysis of Psychophysiological Responses in Fibromyalgia Patients: Evaluating Neuromodulation Alone, Neuromodulation Combined with Virtual Reality, and Exercise Interventions.Medicina (Kaunas, Lithuania) · 2024Trial
- Effect of vitamin B6 on pain, disease severity, and psychological profile of fibromyalgia patients; a randomized, double-blinded clinical trial.BMC musculoskeletal disorders · 2022Trial
- What do we know about medical invalidation and related concepts? - A scoping review and thematic analysis about the definitions, measurements, causes, consequences and potential solutions for medical invalidation.BMC health services research · 2026Article
- Self-Reported Symptom Burden and Clinical Characteristics in Fibromyalgia: Evidence from a Large Online Survey in Italy.Medicina (Kaunas, Lithuania) · 2026Article
- Article
- Investigation of the Effectiveness of Mindfulness-Based Yoga Training in Individuals with Fibromyalgia: A Randomized Controlled Trial.Healthcare (Basel, Switzerland) · 2026Article
- Impact of fibromyalgia syndrome diagnosis and treatment experiences on health information-seeking behaviour: A cross-sectional online survey.British journal of pain · 2026Article
- Loneliness is associated with depression, anxiety, pain, and suffering in fibromyalgia: results from a structural equation modeling analysis.Rheumatology international · 2026Observational
- Efficacy and safety of hyperbaric oxygen therapy for women with fibromyalgia: a systematic review and meta-analysis of randomized controlled trials.Reumatologia · 2026Article
- Knowledge, perception and attitude toward fibromyalgia among physical therapists in the United Arab Emirates: A cross-sectional study.PloS one · 2026Article
- Graph theory-based machine learning for automated fibromyalgia diagnosis using fMRI during an emotional task.PloS one · 2026Article
- Prevalence of fibromyalgia in asthma and its impact on asthma control: a case-control study.Annals of medicine · 2025Article
- Circulating FGF-21 as a Disease-Modifying Factor Associated with Distinct Symptoms and Cognitive Profiles in Myalgic Encephalomyelitis and Fibromyalgia.International journal of molecular sciences · 2025Article
- Spinal manipulation for fibromyalgia: a narrative review.The Journal of the Canadian Chiropractic Association · 2025Article
- Impact of Manual Therapy on Plantar Pressures in Patients with Fibromyalgia: A Single-Arm, Non-Randomized Pilot Clinical Trial.Healthcare (Basel, Switzerland) · 2025Article
- Article
- Fibromyalgia, Depression, and Autoimmune Disorders: An Interconnected Web of Inflammation.Biomedicines · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The World Health Organization regards chronic pain to be a public health concern. In clinical medicine, fibromyalgia (FM) is the most prevalent chronic widespread pain disease. In terms of impairment, consumption of health and social resources, and impact on primary and speciality care systems, it has reached worrisome proportions. This disease is frequently managed by primary care providers. Because of its intricacy, fibromyalgia diagnosis and treatment can be difficult. Fibromyalgia is a controversial condition. It might appear ill-defined in comparison to other pain conditions, with no clear knowledge of pathophysiology and hence no particular targeted therapy. This invariably sparks debates and challenges. There is no obvious cut-off point that distinguishes FM from non-FM. The diagnosis of fibromyalgia has been complicated by several factors, including patients' health-seeking behaviour, symptom identification, and physician labelling of the disease. Fibromyalgia is currently considered a centralized pain condition, according to research that has improved our understanding of its etiopathology. A multidisciplinary strategy combining pharmacological and non-pharmacological therapies based on a biopsychosocial paradigm can result in effective therapy. Cultural and psychosocial variables appear to be a recent development in fibromyalgia, and they appear to have a larger influence on physician diagnosis than severe symptom levels in FM patients. Although physicians rely on FM criteria as the only way to classify FM patients in research and clinical settings, some crucial elements of the diagnostic challenge of fibromyalgia remain unsolved - invalidation, psychosocial variables, and diverse illness manifestation are some examples. Beyond the existing constructional scores, physicians' judgment gained in real communicative contexts with patients, appears to be the only dependable route for a more accurate diagnosis for fibromyalgia. We have performed an exhaustive review of the literature using the keywords "Fibromyalgia", "challenges" and "diagnosis" in PubMed and Google Scholar indexes up to September 2021. This article aims to examine the causes, diagnosis, and current treatment protocols of FM, as well as discuss some continuing debates and diagnostic challenges which physicians face in accurately diagnosing fibromyalgia.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.