Evidence map›Paper›PMID 34786178›Full record

ArticleWorld journal of hepatology2021

Clinical outcomes of patients with two small hepatocellular carcinomas.

Anh Duy Pham, Karl Vaz, Zaid S Ardalan, Marie Sinclair, Ross Apostolov, Sarah Gardner, Ammar Majeed, Gauri Mishra, Ning Mao Kam, Kurvi Patwala and 13 more

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in World journal of hepatology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.1field-weighted citation impact, top 52% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors at 3 institutions in 1 country.

Anh Duy PhamThe Victorian Liver Transplant Unit, Austin Health, Heidelberg 3084, Victoria, Australia.
Karl VazThe Victorian Liver Transplant Unit, Austin Health, Heidelberg 3084, Victoria, Australia. karl.vaz@austin.org.au.
Zaid S ArdalanThe Victorian Liver Transplant Unit, Austin Health, Heidelberg 3084, Victoria, Australia.
Marie SinclairThe Victorian Liver Transplant Unit, Austin Health, Heidelberg 3084, Victoria, Australia.
Ross ApostolovThe Victorian Liver Transplant Unit, Austin Health, Heidelberg 3084, Victoria, Australia.
Sarah GardnerThe Victorian Liver Transplant Unit, Austin Health, Heidelberg 3084, Victoria, Australia.
Ammar MajeedDepartment of Gastroenterology, Alfred Health, Melbourne 3000, Victoria, Australia.
Gauri MishraDepartment of Gastroenterology and Hepatology, Monash Health, Clayton 3168, Victoria, Australia.
Ning Mao KamThe Victorian Liver Transplant Unit, Austin Health, Heidelberg 3084, Victoria, Australia.
Kurvi PatwalaThe Victorian Liver Transplant Unit, Austin Health, Heidelberg 3084, Victoria, Australia.
Numan KutaibaDepartment of Radiology, Austin Health, Heidelberg 3084, Victoria, Australia.
Niranjan ArachchiThe Melbourne Liver Group, Melbourne 3000, Victoria, Australia.
Sally BellThe Melbourne Liver Group, Melbourne 3000, Victoria, Australia.
Anouk T DevThe Melbourne Liver Group, Melbourne 3000, Victoria, Australia.
John S LubelDepartment of Gastroenterology, Alfred Health, Melbourne 3000, Victoria, Australia.
Amanda J NicollThe Melbourne Liver Group, Melbourne 3000, Victoria, Australia.
Siddharth SoodThe Melbourne Liver Group, Melbourne 3000, Victoria, Australia.
William KempDepartment of Gastroenterology, Alfred Health, Melbourne 3000, Victoria, Australia.
Stuart K RobertsDepartment of Gastroenterology, Alfred Health, Melbourne 3000, Victoria, Australia.
Michael FinkThe Victorian Liver Transplant Unit, Austin Health, Heidelberg 3084, Victoria, Australia.
Adam G TestroThe Victorian Liver Transplant Unit, Austin Health, Heidelberg 3084, Victoria, Australia.
Peter W AngusThe Victorian Liver Transplant Unit, Austin Health, Heidelberg 3084, Victoria, Australia.
Paul J GowThe Victorian Liver Transplant Unit, Austin Health, Heidelberg 3084, Victoria, Australia.
Austin Health · AUAlfred Health · AUMonash Health · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundManagement of single small hepatocellular carcinoma (HCC) is straightforward with curative outcomes achieved by locoregional therapy or resection. Liver transplantation is often considered for multiple small or single large HCC. Management of two small HCC whether presenting synchronously or sequentially is less clear.

aimTo define the outcomes of patients presenting with two small HCC.

methodsRetrospective review of HCC databases from multiple institutions of patients with either two synchronous or sequential HCC ≤ 3 cm between January 2000 and March 2018. Primary outcomes were overall survival (OS) and transplant-free survival (TFS).

results104 patients were identified (male

conclusionTFS in patients presenting with two HCC ≤ 3 cm is poor regardless of the timing of the second tumor. All patients presenting with two small HCC should be considered for transplantation.

Indexed as

Hepatocellular carcinomaLiver cancerPrognosisTransplantationTransplant-free survival

Identifiers

PMID34786178
PMCPMC8568581
OpenAlexW3208926747

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.