Evidence map›Paper›PMID 34786150›Full record

ReviewWorld journal of stem cells2021

Unveiling the morphogenetic code: A new path at the intersection of physical energies and chemical signaling.

Riccardo Tassinari, Claudia Cavallini, Elena Olivi, Valentina Taglioli, Chiara Zannini, Carlo Ventura

Open access · bronzeAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in World journal of stem cells, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Riccardo TassinariNational Laboratory of Molecular Biology and Stem Cell Engineering, National Institute of Biostructures and Biosystems - ELDOR LAB, Bologna 40129, Italy.
Claudia CavalliniNational Laboratory of Molecular Biology and Stem Cell Engineering, National Institute of Biostructures and Biosystems - ELDOR LAB, Bologna 40129, Italy.
Elena OliviNational Laboratory of Molecular Biology and Stem Cell Engineering, National Institute of Biostructures and Biosystems - ELDOR LAB, Bologna 40129, Italy.
Valentina TaglioliNational Laboratory of Molecular Biology and Stem Cell Engineering, National Institute of Biostructures and Biosystems - ELDOR LAB, Bologna 40129, Italy.
Chiara ZanniniNational Laboratory of Molecular Biology and Stem Cell Engineering, National Institute of Biostructures and Biosystems - ELDOR LAB, Bologna 40129, Italy.
Carlo VenturaNational Laboratory of Molecular Biology and Stem Cell Engineering, National Institute of Biostructures and Biosystems - ELDOR LAB, Bologna 40129, Italy. carlo.ventura@unibo.it.
Jackson and Tull (United States) · USCreative Research Enterprises (United States) · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In this editorial, we discuss the remarkable role of physical energies in the control of cell signaling networks and in the specification of the architectural plan of both somatic and stem cells. In particular, we focus on the biological relevance of bioelectricity in the pattern control that orchestrates both developmental and regenerative pathways. To this end, the narrative starts from the dawn of the first studies on animal electricity, reconsidering the pioneer work of Harold Saxton Burr in the light of the current achievements. We finally discuss the most recent evidence showing that bioelectric signaling is an essential component of the informational processes that control pattern specification during embryogenesis, regeneration, or even malignant transformation. We conclude that there is now mounting evidence for the existence of a Morphogenetic Code, and that deciphering this code may lead to unprecedented opportunities for the development of novel paradigms of cure in regenerative and precision medicine.

Indexed as

BioelectricityElectromagnetic radiationMechanical forcesMorphogenetic codePhysical energiesStem cells

Identifiers

PMID34786150
PMCPMC8567452
OpenAlexW3210173965

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.