ArticleAmerican journal of translational research2021
Effects of adjuvant pidotimod therapy on levels of inflammatory factors and expressions of serum GM-CSF and KL-6 in elderly patients with mycoplasma pneumonia.
Article in American journal of translational research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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Who cites it
3 citing papers in PubMed, 3 citations in OpenAlex.
- Reducing HPV Viral Burden in Men: A Synergistic Approach Using Pidotimod and Prophylactic Vaccination.Microorganisms · 2026Article
- From Legacy to Innovation: Pidotimod's Expanding Therapeutic Horizon.Mediterranean journal of hematology and infectious diseases · 2025Review
- Interaction between alveolar macrophages and epithelial cells duringFrontiers in cellular and infection microbiology · 2023Review
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo observe the intervention effects of adjuvant pidotimod therapy on the serum inflammatory factor and GM-CSF and KL-6 expression levels in elderly mycoplasma pneumonia patients.
methodsElderly patients (n=104) diagnosed with mycoplasma pneumonia were divided into a control group (52 cases, given conventional anti-infective therapy combined with ambroxol) and a research group (52 cases, given conventional anti-infective therapy combined with ambroxol + pidotimod) according to the different treatment methods each patient was administered. The pulmonary function indexes (FVC, FEV1, FEV1/FVC), the serum inflammatory factor levels (interleukin (IL)-6, IL-8, the tumor necrosis factor α), the serum granulocyte-macrophage colony-stimulating factor (GM-CSF), and the Krebs von den Lungen-6 (KL-6) expression levels were measured before and after the treatment. The cough stopping times, the rale disappearance times, the hospital stay durations, the overall response rates, the incidences of adverse reactions during the administration, and the recurrence rates at 3, 6, and 12 months after the treatment were recorded.
resultsThe research group had shorter cough stopping times, rale disappearance times, and hospital stays than the control group (all P<0.05). After the treatment, the FVC, FVE1, and FVE1/FVC levels in both groups were increased, and the research group had higher levels than the control group (all P<0.05). After the treatment, the serum tumor necrosis factor α, IL-6, IL-8, GM-CSF, and KL-6 levels in the two groups were significantly decreased, and the levels of these indicators in the research group were significantly lower than they were in the control group (all P<0.05). The total overall treatment response rate was higher, and the recurrence rate at 12 months after the treatment was significantly lower in the research group than they were in the control group (P<0.05).
conclusionAdjuvant pidotimod therapy in the treatment of elderly patients with mycoplasma pneumonia can ameliorate patients' inflammatory responses and pulmonary functions, and reduce the serum GM-CSF and KL-6 factor levels, as well as the recurrence rate. Moreover, the combined medication is safe, and no significant increase in toxicity was found.
Indexed as
Identifiers
34786120PMC8581901W3211498542What OpenQuestion holds
Registered trials
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