Evidence map›Paper›PMID 34786051›Full record

ArticleAmerican journal of translational research2021

The effect of cullin 4A on lung cancer cell chemosensitivity to paclitaxel through p33ING1b regulation.

Jrhau Lung, Yi-Chuan Chen, Yu-Ching Lin, Ya-Chin Li, Liang You, David M Jablons, Jian-Hua Mao, Cheng-Ta Yang, Ming-Szu Hung

Open access · greenAbstract read
PubMed Full text at PMC
In one paragraph

Article in American journal of translational research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 50% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Jrhau LungDepartment of Medical Research, Chang Gung Memorial Hospital, Chiayi Branch Chiayi 61363, Taiwan.
Yi-Chuan ChenDepartment of Emergency Medicine, Madou Sin-Lau Hospital, The Presbyterian Church in Taiwan Tainan 72100, Taiwan.
Yu-Ching LinDepartment of Medicine, College of Medicine, Chang Gung University Taoyuan 33323, Taiwan.
Ya-Chin LiDepartment of Pulmonary and Critical Care Medicine, Chang Gung Memorial Hospital, Chiayi Branch Chiayi 61363, Taiwan.
Liang YouThoracic Oncology Laboratory, Department of Surgery, Comprehensive Cancer Center, University of California San Francisco, CA 94143, USA.
David M JablonsThoracic Oncology Laboratory, Department of Surgery, Comprehensive Cancer Center, University of California San Francisco, CA 94143, USA.
Jian-Hua MaoLawrence Berkeley National Laboratory, Life Sciences Division One Cyclotron Road, Berkeley, California, CA 94720, USA.
Cheng-Ta YangDepartment of Respiratory Care, College of Medicine, Chang Gung University Taoyuan 33323, Taiwan.
Ming-Szu HungDepartment of Medicine, College of Medicine, Chang Gung University Taoyuan 33323, Taiwan.
UCSF Helen Diller Family Comprehensive Cancer Center · USUniversity of California, San Francisco · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cullin 4A (Cul4A) reportedly has oncogenic roles in several cancer types by regulating tumor suppressors through the ubiquitination and proteolysis of the tumor suppressor. In addition, Cul4A is associated with chemosensitivity to chemotherapy drugs. This study investigated the association between Cul4A and lung cancer cell chemosensitivity to paclitaxel, particularly with respect to the role of the p33 inhibitor of the growth 1 (p33ING1b) tumor suppressor. The results showed that the Cul4A knockdown upregulated the p33ING1b expression in lung cancer cells and increased the lung cancer cell and mice tumor xenograft chemosensitivity to paclitaxel. The Cul4A knockdown also inhibited the growth and increased the apoptosis in the tumor xenografts treated with paclitaxel. Notably, the p33ING1b overexpression increased the lung cancer cell chemosensitivity to paclitaxel, but the p33ING1b knockdown reduced the chemosensitivity. A further analysis demonstrated that Cul4A regulates the expression of p33ING1b through protein-protein interactions, ubiquitination, and protein degradation. In conclusion, the present findings suggest that Cul4A mediates the chemosensitivity of lung cancer cells to paclitaxel by regulating p33ING1b. These findings may offer novel insights into future therapeutic strategies for lung cancer that target Cul4A.

Indexed as

cullin 4ALung cancerpaclitaxel

Identifiers

PMID34786051
PMCPMC8581858
OpenAlexW3214106963

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.