ReviewAmerican journal of translational research2021
Bidirectional regulation of bile acid on colorectal cancer through bile acid-gut microbiota interaction.
Review in American journal of translational research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
9 citing papers in PubMed, 1 synthesis or guideline pooled it, 12 citations in OpenAlex.
- Cholecystectomy promotes the development of colorectal cancer by the alternation of bile acid metabolism and the gut microbiota.Frontiers in medicine · 2022Pooled it
- Long-term risk of colorectal cancer following cholecystectomy: a nationwide cohort study.Surgical endoscopy · 2026Article
- β-Glucuronidase at the Microbiota-Host Interface: Dual Regulatory Roles and Precision Modulation by Natural Products.Molecules (Basel, Switzerland) · 2026Review
- High-fat diet driven post-operative colon cancer recurrence is dependent upon genetic susceptibility to deoxycholic acid.Cancer letters · 2025Article
- The Impact of Cholecystectomy on Colorectal Cancer Risk: A Comprehensive Review on Risk Factors and the Association.Current gastroenterology reports · 2025Review
- Alteration of ascending colon mucosal microbiota in patients after cholecystectomy.World journal of gastrointestinal surgery · 2024Article
- Gut Microbial and Associated Metabolite Markers for Colorectal Cancer Diagnosis.Microorganisms · 2023Review
- Investigation of trends in gut microbiome associated with colorectal cancer using machine learning.Frontiers in oncology · 2023Article
- The human microbiome in disease and pathology.APMIS : acta pathologica, microbiologica, et immunologica Scandinavica · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Colorectal cancer (CRC) is now the third most common malignancy and the second leading cause of cancer death globally. Bile acid has bidirectional regulatory effects on CRC and influences its progression by interacting with gut microbiota. In this review, we provide evidence for bidirectional regulation of bile acid on CRC at multi-level and discuss the communication of gene, immune, metabolism and diet in the context of CRC with bile acid-gut microbiota interaction. The study on bidirectional regulation of bile acid is helpful to provide a more comprehensive and in-depth understanding of CRC pathogenesis and expect to be a new option for the treatment of CRC.
Indexed as
Identifiers
34786038PMC8581861W3213496129What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.