Evidence map›Paper›PMID 34786034›Full record

ArticleThe World Allergy Organization journal2021

ARIA-ITALY multidisciplinary consensus on nasal polyposis and biological treatments.

Carlo Lombardi, Riccardo Asero, Diego Bagnasco, Francesco Blasi, Matteo Bonini, Mario Bussi, Rikki F Canevari, Giorgio Walter Canonica, Paolo Castelnuovo, Lorenzo Cecchi and 23 more

Open access · goldAbstract read
In one paragraph

Article in The World Allergy Organization journal, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
4.4field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 30 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Review
  6. Review
  7. Article
  8. Review
  9. Review
  10. Dupilumab: a delayed response in asthmatic and atopic patients treated for chronic rhinosinusitis with nasal polyps.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2024
    Article
  11. Article
  12. Review
  13. Review
  14. Practical recommendations for managing severe chronic rhinosinusitis with nasal polyps in the era of biologics.Acta otorhinolaryngologica Italica : organo ufficiale della Societa italiana di otorinolaringologia e chirurgia cervico-facciale · 2023
    Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

33 authors at 20 institutions in 1 country.

Carlo LombardiUnit of Allergology, Clinical Immunology & Respiratory Diseases, Fondazione Poliambulanza, Brescia, Italy.
Riccardo AseroAmbulatorio di Allergologia, Clinica San Carlo, Paderno Dugnano, MI, Italy.
Diego BagnascoAllergy and Respiratory Diseases, IRCCS Policlinico S.Martino, University of Genoa, Italy.
Francesco BlasiDipartimento Fisiopatologia Medico-chirurgica e Trapianti Università di Milano, IRCCS Fondazione Cà Granda, Policlinico di Milano, Italy.
Matteo BoniniDipartimento di Scienze Cardiovascolari e Toraciche, Università Cattolica del Sacro Cuore, Roma, Italy.
Mario BussiUnità Operativa di Otorinolaringoiatria Ospedale Universitario I.R.C.C.S. San Raffaele, Milan, Italy.
Rikki F CanevariDipartimento DISC Clinica Otorinolaringoiatra IRCCS Policlinico San Martino, Università di Genova, Italy.
Giorgio Walter CanonicaPersonalized Medicine, Asthma and Allergy, Humanitas Research Hospital, Rozzano, Milan, Italy.
Paolo CastelnuovoDBSV, Clinica ORL, Università Insubria, ASST-settelaghi, HNS&FDR Center, Varese, Italy.
Lorenzo CecchiSOS Allergologia e Immunologia Clinica Prato, USL Toscana Centro, Italy.
Lorenzo CosmiDepartment of Experimental and Clinical Medicine, University of Florence, Italy.
Matteo GelardiClinica Otorinolaringoiatrica, Dipartimento di Medicina Clinica e Sperimentale, Università di Foggia, Italy.
Enrico HefflerPersonalized Medicine, Asthma and Allergy, Humanitas Research Hospital, Rozzano, Milan, Italy.
Luciana IndinnimeoUniversità degli Studi di Roma "Sapienza", Direttore Scientifico di Area Pediatrica, Società Italiana di Pediatria, Italy.
Massimo LandiPediatric National Healthcare System, Turin, Institute of Biomedical Research and Innovation Palermo, Italy.
Amelia LicariDepartment of Pediatrics, Fondazione IRCCS Policlinico San Matteo, University of Pavia, Italy.
Francesco LiottaDepartment of Experimental and Clinical Medicine, University of Florence, Italy.
Alberto MacchiClinica ORL, Asst Settelaghi Varese, Università degli Studi dell' Insubria, Varese, Italy.
Luca MalvezziOtorhinolaryngology Unit, Humanitas University, Humanitas Clinical & Research Center, Rozzano, MI, Italy.
Gianluigi MarsegliaDepartment of Pediatrics, Fondazione IRCCS Policlinico San Matteo, University of Pavia, Italy.
Claudio MichelettoUOC Pneumologia, Azienda Ospedaliera Universitaria, Verona, Italy.
Antonino MusarraServizio di Allergologia, Casa della Salute di Scilla, ASP di Reggio Calabria, Italy.
Diego PeroniPediatrics, Dept. of Experimental Medicine, University of Pisa, Italy.
Giorgio PiacentiniDipartimento di Scienze Chirurgiche, Odontostomatologiche e Materno-Infantili Università di Verona, Italy.
Venerino PolettiDipartimento Toracico Azienda USL ROMAGNA (I), Italy.
Luca RicheldiUOC DI PNEUMOLOGIA, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Italy.
Angela SantoniDipartimento di Medicina Molecolare, Università; "Sapienza", Roma, Italy.
Michele SchiappoliAsthma Center and Allergy Unit, University of Verona and General Hospital, Verona, Italy.
Gianenrico SennaAsthma Center and Allergy Unit, University of Verona and General Hospital, Verona, Italy.
Adriano VaghiASST Rodhense Pneumologia, Italy.
Alberto VillaniUnità Operativa Complessa di Pediatria Generale e Malattie Infettive, Ospedale Pediatrico Bambino Gesù, Roma, Italy.
Giovanni PassalacquaAllergy and Respiratory Diseases, IRCCS Policlinico S.Martino, University of Genoa, Italy.
ARIA Italia
Ospedale Policlinico San Martino · ITUniversity of Verona · ITIRCCS Humanitas Research Hospital · ITUniversity of Florence · ITUniversity of Insubria · ITUniversity of Pavia · ITAgostino Gemelli University Polyclinic · ITAzienda Ospedaliera Universitaria Integrata Verona · ITAzienda Unità Sanitaria Locale Della Romagna · ITAzienda Usl Toscana Centro · ITBambino Gesù Children's Hospital · ITFondazione Poliambulanza Istituto Ospedaliero · ITHumanitas University · ITInstitute for Biomedical Research and Innovation · ITOspedale San Carlo · ITSapienza University of Rome · ITUniversità Cattolica del Sacro Cuore · ITUniversity of Foggia · ITUniversity of Milan · ITUniversity of Pisa · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In the recent years, it was recognized that type-2 inflammation links many forms of nasal polyposis with severe asthma. Thus, some biological drugs developed for severe asthma appeared to exert an effect on nasal polyposis. So far, there are several trials supporting this concept; therefore, some monoclonal antibodies for severe asthma were assessed also in polyposis, with promising results. Since different specialists are involved in the management of nasal polyposis (eg, pulmonologists, ENT, allergists), it was felt that an educational and informative document was needed to better identify the indications of biologicals in nasal polyposis. We collected the main Italian Scientific Societies, and prepared (under the Allergic Rhinitis and its Impact on Asthma, ARIA) a document endorsed by all Societies, to provide a provisional statement for the future use of monoclonal antibodies as a medical treatment for polyposis. It is the first nationwide endorsed document on this aspect. The current pathogenic knowledge and the experimental evidence are herein reviewed, and some suggestions for a correct prescription and follow-up are provided.

Indexed as

ARIABiological antibodiesCRSwNPNasal polypsPersonalized medicine

Identifiers

PMID34786034
PMCPMC8573187
OpenAlexW3210895333

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.