ReviewThe EPMA journal2021
Homocysteine metabolism as the target for predictive medical approach, disease prevention, prognosis, and treatments tailored to the person.
Review in The EPMA journal, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 102 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
102 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Prevalence of hyperhomocysteinemia in South Asian patients with heart disease: a systematic review and meta-analysis.BMC cardiovascular disorders · 2026Pooled it
- The association of plasma homocysteine levels with short-term mortality in sepsis patients: A meta-analysis.Biomolecules & biomedicine · 2025Pooled it
- Tai Chi modulating multimodal connectivity patterns and cognitive function in cerebral small vessel disease.GeroScience · 2026Trial
- Follicular homocysteine as a marker of oocyte quality in PCOS and the role of micronutrients.Journal of assisted reproduction and genetics · 2023Trial
- Association of elevated homocysteine levels with renal pathology and function in patients with IgA nephropathy: a single-center retrospective study.Annals of medicine · 2026Article
- Non-canonical ceRNA-independent mechanism of the lncRNA-H19/miR-212-5p axis targeting KLF4 in Hcy-triggered VSMCs dysfunction and atherogenesis.Scientific reports · 2026Article
- The complex link of the folate-homocysteine axis to myocardial hypertrophy and heart failure: from mechanistic exploration to clinical vision.Journal of advanced research · 2026Review
- Evaluation of serum and dietary profiles of vitamin B12 and folate and their association with systemic complications in patients with Crohn's disease.European journal of clinical nutrition · 2026Article
- SHMT2 deficiency disrupts transcriptional regulation through homocysteine-mediated suppression of histone lactylation in Huntington's disease models.The Journal of clinical investigation · 2026Article
- Accelerated epigenetic aging as a modifier of homocysteine-associated cognitive decline: Findings from NHANES.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Diagnostic and prognostic value of serum Hcy and aMMP-8 levels in patients with acute pancreatitis : Value of serum Hcy and aMMP-8 in AP.Langenbeck's archives of surgery · 2026Article
- Psychosis in the aftermath of stroke: Pyridoxine-responsive homocystinuria in an adolescent.Indian journal of psychiatry · 2026Article
- Modulating One-Carbon Metabolism with B-Vitamins to Protect the Retinal Barrier and Prevent Retinal Degeneration.Nutrients · 2026Article
- Research Progress on the Effect of Exercise on Homocysteine.Current medicinal chemistry · 2026Review
- The study on serum oxidized low-density lipoprotein and homocysteine as cardiovascular risk markers in subclinical hypothyroidism patients.Frontiers in endocrinology · 2026Article
- MTHFR variant links homocysteine metabolism and endothelial cell dysfunction by targeting mitophagy in human thoracic aortic dissection patient induced pluripotent stem cell (iPSC) models.Journal of advanced research · 2025Article
- Article
- Serum Homocysteine and Its Diagnostic Significance in Oral Submucous Fibrosis: A Cross-Sectional Study.Asian Pacific journal of cancer prevention : APJCP · 2025Article
- Serum homocysteine-based traffic light triage colonoscopy screening in colorectal cancer at-risk patients: A prospective cohort study.World journal of gastroenterology · 2025Article
- Establishment of reference intervals for serum immunoglobulin GThe EPMA journal · 2025Article
42 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Homocysteine (Hcy) metabolism is crucial for regulating methionine availability, protein homeostasis, and DNA-methylation presenting, therefore, key pathways in post-genomic and epigenetic regulation mechanisms. Consequently, impaired Hcy metabolism leading to elevated concentrations of Hcy in the blood plasma (hyperhomocysteinemia) is linked to the overproduction of free radicals, induced oxidative stress, mitochondrial impairments, systemic inflammation and increased risks of eye disorders, coronary artery diseases, atherosclerosis, myocardial infarction, ischemic stroke, thrombotic events, cancer development and progression, osteoporosis, neurodegenerative disorders, pregnancy complications, delayed healing processes, and poor COVID-19 outcomes, among others. This review focuses on the homocysteine metabolism impairments relevant for various pathological conditions. Innovative strategies in the framework of 3P medicine consider Hcy metabolic pathways as the specific target for in vitro diagnostics, predictive medical approaches, cost-effective preventive measures, and optimized treatments tailored to the individualized patient profiles in primary, secondary, and tertiary care.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.