ArticleCardiovascular therapeutics2021
The Association between the Serum Uric Acid Level and Hypertension in Middle-Aged and Elderly Adults.
Article in Cardiovascular therapeutics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- The Nonlinear Relationship Between Serum Uric Acid and Cardiovascular Disease Risk: Mechanistic Insights and Clinical Implications.Cardiovascular drugs and therapy · 2026Review
- Serum Uric Acid and Mortality Risk in Chronic Kidney Disease: A Dose-Response Analysis.Journal of clinical medicine · 2026Article
- Associations of serum uric acid trajectories with hypertension risk: exploring differences between age groups.Frontiers in cardiovascular medicine · 2025Article
- Metabolic Effects of Selected Conventional and Alternative Sweeteners: A Narrative Review.Nutrients · 2024Review
- Clinical effects of a selective urate reabsorption inhibitor dotinurad in patients with hyperuricemia and treated hypertension: a multicenter, prospective, exploratory study (DIANA).European journal of medical research · 2023Article
- Association between Dietary Acid Load and Hyperuricemia in Chinese Adults: Analysis of the China Health and Nutrition Survey (2009).Nutrients · 2023Article
- Association between serum uric acid levels and achievement of target blood pressure among Japanese community residents with hypertension.Journal of clinical hypertension (Greenwich, Conn.) · 2023Article
- Serum Uric Acid and Hyperuricemia Associate with Coronary Artery Disease among Postmenopausal Women.Reviews in cardiovascular medicine · 2022Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundStudies on serum uric acid (sUA) levels and hypertension (HTN) are controversial. To investigate the association between the sUA level and the incident of HTN in middle-aged and elderly adults, we performed this study.
methods6399 participants aged ≥40 years from the National Health and Nutrition Examination Survey (NHANES) were included. Weighted multiple logistic regression analysis was carried out to evaluate the relationship between the sUA level and the incident of HTN, exploring the potential nonlinear relationship using the fitted smoothing curves. If nonlinearity was observed, the inflection point was further calculated by a recursive algorithm.
resultsA positive relationship between the sUA level and the incident of HTN was found. However, it may differ in different race groups, nor between male and female. Moreover, the association between the sUA level and the incident of HTN followed a U-shaped curve in male (turning point: sUA 4.1 mg/dL) and Whites (turning point: sUA 7.9 mg/dL).
conclusionsThe results revealed that the sUA level is positively correlated with the incident of HTN, in middle-aged and elderly adults. However, it followed a U-shaped curve in males and Whites.
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