ArticleNature and science of sleep2021
Gut Microbiota in Patients with Type 1 Narcolepsy.
Article in Nature and science of sleep, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 12 citations in OpenAlex.
- From alpha diversity to zeitgebers: Bacterial gut microbiome associations with sleep and circadian disruption (Part I).Neuroscience and biobehavioral reviews · 2026Review
- Microbial-Immune Interplay in CNS Autoimmune Diseases: Lessons from Animal Models and Clinical Studies.European journal of immunology · 2026Review
- Association between cytokines and neuropsychiatric symptoms in paediatric narcolepsy patients: a cross-sectional study.BMC neurology · 2025Article
- Genetically predicted plasma metabolites mediate the causal relationship between gut microbiota and osteosarcoma.Scientific reports · 2025Article
- Insomnia and intestinal microbiota: a narrative review.Sleep & breathing = Schlaf & Atmung · 2024Review
- Relationship between type 1 narcolepsy and gut microbiota: sleepy people, sleepy microbiota?Sleep · 2024Article
- Alternations in the human skin, gut and vaginal microbiomes in perimenopausal or postmenopausal Vulvar lichen sclerosus.Scientific reports · 2024Article
- Gut microbiota and sleep: Interaction mechanisms and therapeutic prospects.Open life sciences · 2024Review
- Association between sleep-related phenotypes and gut microbiota: a two-sample bidirectional Mendelian randomization study.Frontiers in microbiology · 2024Article
- Microbiota Composition and Probiotics Supplementations on Sleep Quality-A Systematic Review and Meta-Analysis.Clocks & sleep · 2023Review
- Association ofOpen life sciences · 2023Article
- The role of gut microbiota in diabetic peripheral neuropathy rats with cognitive dysfunction.Frontiers in microbiology · 2023Article
- New Perspectives on Sleep Regulation by Tea: Harmonizing Pathological Sleep and Energy Balance under Stress.Foods (Basel, Switzerland) · 2022Review
- Examining the Relationships Between Sleep Physiology and the Gut Microbiome in Preclinical and Translational Research: Protocol for a Scoping Review.JMIR research protocols · 2022Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo explore the characteristics of gut microbiota and its relationship between clinical manifestations in patients with type 1 narcolepsy (NT1). PATIENTS AND
methodsScale and polysomnography were performed in 20 NT1 patients and 16 healthy controls (HC group) to evaluate the clinical characteristics of NT1. Illumina sequencing was performed on bacterial 16S ribosomal RNA gene using V3-V4 regions to compare the fecal microbiota in all subjects. Associations between clinical characteristics and gut microbiota were analyzed using partial correlation analysis.
resultsCompared with the HC group, the NT1 group had a significantly higher ESS score, longer total sleep time, increased wakefulness, decreased sleep efficiency, disturbance of sleep structure, shorter mean sleep latency, and increased sleep-onset REM periods (all P < 0.05). No differences in alpha and beta diversity were observed between the two groups. In contrast, there were significant differences at the level of class, order, family, and genus (all P < 0.05). LEfSe analysis showed that the relative abundance of
conclusionOur data revealed differences in intestinal flora structure between NT1 patients and the normal population, thus providing a theoretical basis for future microecological therapy for narcolepsy. However, future larger sample size studies and different study designs are needed to further clarify the possible pathogenesis and potential causality of intestinal flora in NT1 patients and explore the new treatment strategies.
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