Evidence map›Paper›PMID 34785911›Full record

ArticleJournal of asthma and allergy2021

Impact of Socioeconomic Status on Adult Patients with Asthma: A Population-Based Cohort Study from UK Primary Care.

John Busby, David Price, Riyad Al-Lehebi, Sinthia Bosnic-Anticevich, Job F M van Boven, Benjamin Emmanuel, J Mark FitzGerald, Mina Gaga, Susanne Hansen, Mark Hew and 11 more

Abstract read
In one paragraph

Article in Journal of asthma and allergy, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed.

  1. Article
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  5. BetaFrontiers in medicine · 2026
    Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Observational
  14. Observational
  15. Neighborhood Deprivation and Crime on Asthma Exacerbations and Utilization in Mild Adult Asthma.The journal of allergy and clinical immunology. In practice · 2024
    Article
  16. Article
  17. Article
  18. Article
  19. Post-hospitalisation asthma management in primary care: a retrospective cohort study.The British journal of general practice : the journal of the Royal College of General Practitioners · 2024
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

John BusbyCentre for Public Health, Queen's University Belfast, Belfast, Northern Ireland.
David PriceOptimum Patient Care, Cambridge, UK.ORCID 0000-0002-9728-9992
Riyad Al-LehebiDepartment of Pulmonology, King Fahad Medical City, Riyadh, Saudi Arabia.
Sinthia Bosnic-AnticevichSydney Pharmacy School, Faculty of Medicine and Health, The University of Sydney, Sydney, Australia.ORCID 0000-0001-5077-8329
Job F M van BovenDepartment of Clinical Pharmacy & Pharmacology, Groningen Research Institute for Asthma and COPD (GRIAC), University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.ORCID 0000-0003-2368-2262
Benjamin EmmanuelBioPharmaceuticals Medical, AstraZeneca, Gaithersburg, MD, USA.
J Mark FitzGeraldDepartment of Medicine, The University of British Columbia, Vancouver, Canada.
Mina Gaga7th Respiratory Medicine Department and Asthma Centre, Athens Chest Hospital, Athens, Greece.
Susanne HansenCenter for Clinical Research and Prevention, Bispebjerg and Frederiksberg Hospital, Copenhagen, Denmark.
Mark HewAllergy, Asthma & Clinical Immunology Service, Alfred Health, Melbourne, Australia.
Takashi IwanagaCenter for General Medical Education and Clinical Training, Kindai University Hospital, Osakasayama, Japan.ORCID 0000-0001-9155-265X
Désirée Larenas LinnemannDirectora Centro de Excelencia en Asma y Alergia, Hospital Médica Sur, Ciudad de México, Mexico.ORCID 0000-0002-5713-5331
Bassam MahboubCollege of Medicine, University of Sharjah, Sharjah, United Arab Emirates.
Patrick MitchellCumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.
Daniela MorronePersonalized Medicine, Asthma and Allergy, Humanitas Clinical and Research Center, IRCCS, Rozzano, Italy.
Jonathan PhamAllergy, Asthma & Clinical Immunology Service, Alfred Health, Melbourne, Australia.
Celeste PorsbjergRespiratory Research Unit, Bispebjerg University Hospital, Copenhagen, Denmark.
Nicolas RocheRespiratory Medicine, Cochin Hospital, APHP.Centre, Paris, France.ORCID 0000-0002-3162-5033
Eileen WangDivision of Allergy & Clinical Immunology, Department of Medicine, National Jewish Health, Denver, CO, USA.
Neva EleangovanOptimum Patient Care, Cambridge, UK.
Liam G HeaneyWellcome-Wolfson Centre for Experimental Medicine, Queen's University Belfast, Belfast, Northern Ireland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionAsthma morbidity and health-care utilization are known to exhibit a steep socioeconomic gradient. Further investigation into the modulators of this effect is required to identify potentially modifiable factors.

methodsWe identified a cohort of patients with asthma from the Optimum Patient Care Research Database (OPCRD). We compared demographics, clinical variables, and health-care utilization by quintile of the UK 2011 Indices of Multiple Deprivation based on the location of the patients' general practice. Multivariable analyses were conducted using generalized linear models adjusting for year, age, and sex. We conducted subgroup analyses and interaction tests to investigate the impact of deprivation by age, sex, ethnicity, and treatment step.

resultsOur analysis included 127,040 patients with asthma. Patients from the most deprived socio-economic status (SES) quintile were more likely to report uncontrolled disease (OR: 1.54, 95% CI: 1.16, 2.05) and to have an exacerbation during follow-up (OR: 1.27, 95% CI: 1.13, 1.42) than the least deprived quintile. They had higher blood eosinophils (ratio: 1.03; 95% CI: 1.00, 1.06) and decreased peak flow (ratio: 0.95, 95% CI: 0.94, 0.97) when compared to those in the least deprived quintile. The effect of deprivation on asthma control was greater among those aged over 75 years (OR = 1.81, 95% CI: 1.20, 2.73) compared to those aged less than 35 years (OR: 1.22, 95% CI: 0.85, 1.74; p

conclusionWe found worse disease control and increased exacerbation rates among patients with asthma from more deprived areas. There was evidence that the magnitude of socioeconomic disparities was elevated among older patients and those from ethnic minority groups. The drivers of these differences require further exploration.

Indexed as

asthmadisparitiessocioeconomic status

Identifiers

PMID34785911
PMCPMC8591110

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.