ArticleScientific reports2021
Enhanced osseointegration through direct energy deposition porous coating for cementless orthopedic implant fixation.
Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed, 24 citations in OpenAlex.
- Multiscale Interface Engineering for Orthopedic and Dental Implants: A Review.Journal of functional biomaterials · 2026Review
- Porous Coatings by Vapor Sublimation and Deposition for Molecular Channeling and Filtration in an Interstitial Fluid Microfiltration Device.Advanced healthcare materials · 2026Article
- Current 3D Printing Technologies and their Potential Applications in Drug Delivery, Personalized Medicine & Pharmaceutical Sciences.Current drug discovery technologies · 2026Review
- Revolutionizing Orthopedics through Integration of Artificial Intelligence and 3D Printing for Enhanced Patient Care.Indian journal of orthopaedics · 2025Review
- Short-Term Outcomes of Cementless Total Hip Arthroplasty Using a 3D-Printed Acetabular Cup Manufactured by Directed Energy Deposition: A Prospective Observational Study.Journal of clinical medicine · 2025Article
- Effect of Ti6Al4V Alloy Surface and Porosity on Bone Osseointegration: In Vivo Pilot Study in Rabbits.Materials (Basel, Switzerland) · 2025Article
- Cementless fixation in total joint arthroplasty: Factors impacting osseointegration.Journal of clinical orthopaedics and trauma · 2025Review
- Impact of plasma discharge pressure on implant surface properties and osteoblast activities in vacuum-assisted plasma treatment.Scientific reports · 2024Article
- Review
- Comparative studyWorld journal of orthopedics · 2023Article
- Finite Element Analysis of Von Mises Stress in External Fixators for Open Tibial Fractures: A Comparative Study of ASTM F1541-02 and Tibia-Based Models in Indonesian Patients.Healthcare technology lettersArticle
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 1 country.
Funding
Abstract
Direct energy deposition (DED) is a newly developed 3D metal printing technique that can be utilized on a porous surface coating of joint implants, however there is still a lack of studies on what advantages DED has over conventional techniques. We conducted a systematic mechanical and biological comparative study of porous coatings prepared using the DED method and other commercially available technologies including titanium plasma spray (TPS), and powder bed fusion (PBF). DED showed higher porosity surface (48.54%) than TPS (21.4%) and PBF (35.91%) with comparable fatigue cycle. At initial cell adhesion, cells on DED and PBF surface appeared to spread well with distinct actin stress fibers through immunofluorescence study. It means that the osteoblasts bind more strongly to the DED and PBF surface. Also, DED surface showed higher cell proliferation (1.27 times higher than TPS and PBF) and osteoblast cell activity (1.28 times higher than PBF) for 2 weeks culture in vitro test. In addition, DED surface showed better bone to implant contact and new bone formation than TPS in in vivo study. DED surface also showed consistently good osseointegration performance throughout the early and late period of osseointegration. Collectively, these results show that the DED coating method is an innovative technology that can be utilized to make cementless joint implants.
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Registered trials
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