Evidence map›Paper›PMID 34785665›Full record

ArticleNature communications2021

Hydrogen peroxide signaling via its transformation to a stereospecific alkyl hydroperoxide that escapes reductive inactivation.

Raphael F Queiroz, Christopher P Stanley, Kathryn Wolhuter, Stephanie M Y Kong, Ragul Rajivan, Naomi McKinnon, Giang T H Nguyen, Antonella Roveri, Sebastian Guttzeit, Philip Eaton and 5 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.9field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
  2. Article
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  4. Article
  5. Article
  6. Article
  7. Article
  8. The Footprint of Kynurenine Pathway in Cardiovascular Diseases.International journal of tryptophan research : IJTR · 2022
    Review
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 7 institutions in 5 countries.

Raphael F QueirozDepartment of Natural Sciences, Southwest Bahia State University, Vitoria da Conquista, Bahia, Brazil.ORCID http://orcid.org/0000-0002-7757-4286
Christopher P StanleyVictor Chang Cardiac Research Institute, Darlinghurst, New South Wales, Australia.
Kathryn WolhuterVictor Chang Cardiac Research Institute, Darlinghurst, New South Wales, Australia.
Stephanie M Y KongHeart Research Institute, The University of Sydney, Sydney, Australia.ORCID http://orcid.org/0000-0001-6774-9575
Ragul RajivanVictor Chang Cardiac Research Institute, Darlinghurst, New South Wales, Australia.ORCID http://orcid.org/0000-0002-3605-3978
Naomi McKinnonVictor Chang Cardiac Research Institute, Darlinghurst, New South Wales, Australia.
Giang T H NguyenSchool of Chemistry, University of New South Wales, Sydney, New South Wales, Australia.ORCID http://orcid.org/0000-0001-5156-4904
Antonella RoveriDepartment of Molecular Medicine, University of Padova, Padova, Italy.ORCID http://orcid.org/0000-0002-3252-0559
Sebastian GuttzeitKing's College, The Rayne Institute, St Thomas' Hospital, London, UK.ORCID http://orcid.org/0000-0003-3421-8449
Philip EatonWilliam Harvey Research Institute, Barts and the London School of Medicine, Queen Mary University of London, London, UK.ORCID http://orcid.org/0000-0003-0748-2367
William A DonaldSchool of Chemistry, University of New South Wales, Sydney, New South Wales, Australia.ORCID http://orcid.org/0000-0002-6622-8193
Fulvio UrsiniDepartment of Molecular Medicine, University of Padova, Padova, Italy.
Christine C WinterbournCentre for Free Radical Research, Department of Pathology, University of Otago Christchurch, Christchurch, New Zealand.ORCID http://orcid.org/0000-0003-4160-572X
Anita AyerVictor Chang Cardiac Research Institute, Darlinghurst, New South Wales, Australia. anita.ayer@hri.org.au.ORCID http://orcid.org/0000-0002-7073-2835
Roland StockerVictor Chang Cardiac Research Institute, Darlinghurst, New South Wales, Australia. roland.stocker@hri.org.au.ORCID http://orcid.org/0000-0002-7414-6681
Victor Chang Cardiac Research Institute · AUThe University of Sydney · AUUniversity of Padua · ITUNSW Sydney · AUQueen Mary University of London · GBSt Thomas' Hospital · GBUniversity of Otago · NZ

Funding

British Heart Foundation PG/19/33/34385British Heart Foundation RG/17/16/33294Medical Research Council G0700320Medical Research Council MR/P023150/1Medical Research Council MR/P023150/2Medical Research Council MR/R01065X/1Medical Research Council MR/R01065X/2
6 · The paper itself

Abstract

During systemic inflammation, indoleamine 2,3-dioxygenase 1 (IDO1) becomes expressed in endothelial cells where it uses hydrogen peroxide (H

Indexed as

Signal TransductionAnimalsCyclic GMP-Dependent Protein Kinase Type IEndothelial CellsHomeodomain ProteinsHydrogen PeroxideIndoleamine-Pyrrole 2,3,-DioxygenaseInflammationMaleMiceMice, Inbred C57BLOxidation-ReductionPeroxidasesPeroxiredoxinsTryptophanCyclic GMP-Dependent Protein Kinase Type IHomeodomain ProteinsHydrogen PeroxideIDO1 protein, humanIDO1 protein, mouseIndoleamine-Pyrrole 2,3,-DioxygenasePeroxidasesPeroxiredoxinsPrrx2 protein, mouseTryptophan

Identifiers

PMID34785665
PMCPMC8595612
OpenAlexW3211733484

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.