ArticleNature communications2021
Associations between patterns in comorbid diagnostic trajectories of individuals with schizophrenia and etiological factors.
Article in Nature communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
13 citing papers in PubMed, 22 citations in OpenAlex.
- Potential for Genomics to Help Guide Preventive Strategies in Psychiatry.JAMA psychiatry · 2026Article
- Real-world comprehensive care of people living with schizophrenia: recommendations across different settings and clinical stages.World psychiatry : official journal of the World Psychiatric Association (WPA) · 2026Article
- Article
- Characterisation of serious mental illness trajectories through transdiagnostic clinical features.The British journal of psychiatry : the journal of mental science · 2026Article
- Deep learning-based stratification of Schizophrenia Spectrum Disorder from real-world data reveals distinct profiles of common and rare variant genetic signal.medRxiv : the preprint server for health sciences · 2026Article
- Causal associations between schizophrenia and other psychiatric disorders: A Mendelian randomization study.The Journal of international medical research · 2025Article
- Article
- Assessment and ascertainment in psychiatric molecular genetics: challenges and opportunities for cross-disorder research.Molecular psychiatry · 2025Review
- Unique genetic and risk-factor profiles in clusters of major depressive disorder-related multimorbidity trajectories.Nature communications · 2024Article
- Dementia risk analysis using temporal event modeling on a large real-world dataset.Scientific reports · 2023Article
- Polygenic risk scores enhance prediction of body mass index increase in individuals with a first episode of psychosis.European psychiatry : the journal of the Association of European Psychiatrists · 2023Article
- Towards precision psychiatry utilizing large-scale multimodal data paving the way for improved prevention and treatment of mental disorders.Neuroscience applied · 2023Article
- Associations between patterns in comorbid diagnostic trajectories of individuals with schizophrenia and etiological factors.Nature communications · 2021Article
Corrections and comments
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Authors and funding
14 authors at 8 institutions in 2 countries.
Funding
Abstract
Schizophrenia is a heterogeneous disorder, exhibiting variability in presentation and outcomes that complicate treatment and recovery. To explore this heterogeneity, we leverage the comprehensive Danish health registries to conduct a prospective, longitudinal study from birth of 5432 individuals who would ultimately be diagnosed with schizophrenia, building individual trajectories that represent sequences of comorbid diagnoses, and describing patterns in the individual-level variability. We show that psychiatric comorbidity is prevalent among individuals with schizophrenia (82%) and multi-morbidity occur more frequently in specific, time-ordered pairs. Three latent factors capture 79% of variation in longitudinal comorbidity and broadly relate to the number of co-occurring diagnoses, the presence of child versus adult comorbidities and substance abuse. Clustering of the factor scores revealed five stable clusters of individuals, associated with specific risk factors and outcomes. The presentation and course of schizophrenia may be associated with heterogeneity in etiological factors including family history of mental disorders.
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Registered trials
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