ArticleProceedings of the National Academy of Sciences of the United States of America2021
Handedness and its genetic influences are associated with structural asymmetries of the cerebral cortex in 31,864 individuals.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 66 papers, 2 of them syntheses that pooled it.
What it found
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Who cites it
66 citing papers in PubMed, 2 syntheses or guidelines pooled it, 123 citations in OpenAlex.
- Bipedalism and brain expansion explain human handedness.PLoS biology · 2026Pooled it
- Language and reading impairments are associated with increased prevalence of non-right-handedness.Child developmentPooled it
- The weight of junk food: Smaller hippocampal, amygdala, and prefrontal volumes in adolescents-The Cogni-Action Project.Applied psychology. Health and well-being · 2026Article
- Lateralized Gene Splicing in the Brain is Associated With Lateralized Feeding Behavior in an Asymmetrical Scale-eating Cichlid Fish.Genome biology and evolution · 2026Article
- Earliest evidence of behavioural handedness in the Ediacaran motile bilaterian Spriggina floundersi.Scientific reports · 2026Article
- Variations of global brain asymmetry are associated with aging and related diseases.Science advances · 2026Article
- Nonlinear and intensity-dependent enhancement of sweetness perception as a function of redness: Behavioral and EEG evidence for visual-gustatory cross-modal integration.Food chemistry: X · 2026Article
- Structural and functional brain asymmetry in relation to heterogeneous causes of situs inversus totalis.Brain structure & function · 2026Article
- The Association Between Laterality and Stroke Severity: A Cross-Sectional Study.Health science reports · 2026Article
- Assessing the link among laterality, sex and competitiveness to verify the evolutionarily stable strategy of handedness.Scientific reports · 2026Article
- Hemispheric Asymmetry in Cortical Auditory Processing: The Interactive Effects of Attention and Background Noise.Audiology research · 2026Article
- Non-right-handedness and psychiatric disorders: A synthesis of epidemiological, genetic, and neurobiological evidence.World journal of psychiatry · 2026Review
- Article
- Identifying left and right hemispheres using functional connectivity.bioRxiv : the preprint server for biology · 2025Article
- Asymmetric developmental bifurcations in polarized environments: a new class of human variants, which may include autism.Molecular psychiatry · 2025Review
- Asymmetry in amyotrophic lateral sclerosis: Clinical, neuroimaging and histological observations.Brain : a journal of neurology · 2025Review
- Charting structural brain asymmetry across the human lifespan.bioRxiv : the preprint server for biology · 2025Article
- Developing brain asymmetry shapes cognitive and psychiatric outcomes in adolescence.Nature communications · 2025Article
- Pain Lateralization in Cluster Headache and Associated Clinical Factors.Journal of clinical neurology (Seoul, Korea) · 2025Article
- Cortical neural activity during responses to mechanical perturbation: Effects of hand preference and hand used.NeuroImage · 2025Article
6 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 4 countries.
Funding
Abstract
Roughly 10% of the human population is left-handed, and this rate is increased in some brain-related disorders. The neuroanatomical correlates of hand preference have remained equivocal. We resampled structural brain image data from 28,802 right-handers and 3,062 left-handers (UK Biobank population dataset) to a symmetrical surface template, and mapped asymmetries for each of 8,681 vertices across the cerebral cortex in each individual. Left-handers compared to right-handers showed average differences of surface area asymmetry within the fusiform cortex, the anterior insula, the anterior middle cingulate cortex, and the precentral cortex. Meta-analyzed functional imaging data implicated these regions in executive functions and language. Polygenic disposition to left-handedness was associated with two of these regional asymmetries, and 18 loci previously linked with left-handedness by genome-wide screening showed associations with one or more of these asymmetries. Implicated genes included six encoding microtubule-related proteins:
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.