Evidence map›Paper›PMID 34785580›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2022

Ankyrin-R Links Kv3.3 to the Spectrin Cytoskeleton and Is Required for Purkinje Neuron Survival.

Sharon R Stevens, Meike E van der Heijden, Yuki Ogawa, Tao Lin, Roy V Sillitoe, Matthew N Rasband

Open access · bronzeAbstract read
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 1 pooled it
2.5field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Loss of ANK3 Function Causes a Recessive Neurodevelopmental Disorder with Cerebellar Ataxia.Movement disorders : official journal of the Movement Disorder Society · 2025
    Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Review
  10. Review
  11. Article
  12. Kv3.3 Expression Enhanced by a Novel Variant in the Kozak Sequence ofInternational journal of molecular sciences · 2024
    Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Sharon R StevensDepartment of Neuroscience, Baylor College of Medicine, Houston, Texas 77030.ORCID 0000-0003-2238-8029
Meike E van der HeijdenDepartment Pathology and Immunology, Baylor College of Medicine, Houston, Texas 77030.
Yuki OgawaDepartment of Neuroscience, Baylor College of Medicine, Houston, Texas 77030.
Tao LinDepartment Pathology and Immunology, Baylor College of Medicine, Houston, Texas 77030.
Roy V SillitoeDepartment of Neuroscience, Baylor College of Medicine, Houston, Texas 77030.
Matthew N RasbandDepartment of Neuroscience, Baylor College of Medicine, Houston, Texas 77030 rasband@bcm.edu.ORCID 0000-0001-8184-2477
Baylor College of Medicine · US

Funding

Preclinical and Clincial OutcomesP50HD103555 · NICHD · BAYLOR COLLEGE OF MEDICINE · PI MIRJANA MALETIC-SAVATIC · 2020 to 2026
$9.9M
Steps towards a paternal gene activation therapy for Angelman syndromeU54HD083092 · NICHD · BAYLOR COLLEGE OF MEDICINE · PI ARENKIEL, BENJAMIN R, NELSON, DAVID LOREN · 2014 to 2019
$7.8M
The Molecular Architecture of Axons in Health and DiseaseR35NS122073 · NINDS · BAYLOR COLLEGE OF MEDICINE · PI MATTHEW N RASBAND · 2021 to 2026
$5.6M
Cerebellar Deep Brain StimulationR01NS119301 · NINDS · BAYLOR COLLEGE OF MEDICINE · PI SILLITOE, ROY VINCENT · 2020 to 2024
$2.0M
SYNAPTIC ORIGINS OF CEREBELLAR DISEASER01NS089664 · NINDS · BAYLOR COLLEGE OF MEDICINE · PI SILLITOE, ROY VINCENT · 2014 to 2018
$1.7M
Elucidating the role of Ankyrin-R in the nervous systemF31NS100300 · NINDS · BAYLOR COLLEGE OF MEDICINE · PI STEVENS, SHARON ROSE · 2017 to 2019
$134k
NICHD NIH HHS P50 HD103555NICHD NIH HHS U54 HD083092NINDS NIH HHS F31 NS100300NINDS NIH HHS R01 NS089664NINDS NIH HHS R01 NS119301NINDS NIH HHS R35 NS122073
6 · The paper itself

Abstract

Ankyrin scaffolding proteins are critical for membrane domain organization and protein stabilization in many different cell types including neurons. In the cerebellum, Ankyrin-R (AnkR) is highly enriched in Purkinje neurons, granule cells, and in the cerebellar nuclei (CN). Using male and female mice with a floxed allele for

Indexed as

AnimalsAnkyrinsCell SurvivalCytoskeletonFemaleMaleMicePurkinje CellsShaw Potassium ChannelsSpectrinSpinocerebellar AtaxiasAnkyrinsKcnc3 protein, mouseShaw Potassium ChannelsSpectrinataxiacytoskeletonion channelneurodegeneration

Identifiers

PMID34785580
PMCPMC8741159
OpenAlexW3213354805

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.